Evidence map›Paper›PMID 35932303›Full record

ReviewJournal of cancer research and clinical oncology2022

Modelling reoxygenation effects in non-small cell lung cancer cell lines and showing epithelial-mesenchymal transition.

Joanna Kapeleris, Juliana Müller Bark, Shanon Ranjit, Derek Richard, Ian Vela, Kenneth O'Byrne, Chamindie Punyadeera

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cancer research and clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Examining the contribution of Notch signaling to lung disease development.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Joanna KapelerisCentre for Biomedical Technologies, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, 60 Musk Avenue, GPO Box 2434, Kelvin Grove, QLD, 4059, Australia.
Juliana Müller BarkCentre for Biomedical Technologies, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, 60 Musk Avenue, GPO Box 2434, Kelvin Grove, QLD, 4059, Australia.
Shanon RanjitCentre for Biomedical Technologies, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, 60 Musk Avenue, GPO Box 2434, Kelvin Grove, QLD, 4059, Australia.
Derek RichardCancer & Ageing Research Program, Queensland University of Technology, Translational Research Institute, Woolloongabba, Brisbane, Australia.
Ian VelaAustralian Prostate Cancer Research Centre, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.
Kenneth O'ByrneCancer & Ageing Research Program, Queensland University of Technology, Translational Research Institute, Woolloongabba, Brisbane, Australia.
Chamindie PunyadeeraCentre for Biomedical Technologies, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, 60 Musk Avenue, GPO Box 2434, Kelvin Grove, QLD, 4059, Australia. c.punyadeera@griffith.edu.au.ORCID http://orcid.org/0000-0001-9039-8259
Translational Research Institute · AUGriffith University · AUQueensland University of Technology · AU

Funding

Cancer Australia APP1145657National Health and Medical Research Council APP 2002560National Health and Medical Research Council APP 2002576
6 · The paper itself

Abstract

purposeCirculating tumour cells (CTCs) are a rare cell subpopulation regulated by the tumour microenvironment. In hypoxic conditions, CTCs are able to invade the lymphatic and circulatory systems leading to metastasis at distant sites.

methodsTo mimic in vivo oxygen variations and effects on CTCs, we have cultured five non-small cell lung cancer (NSCLC) cell lines under normoxic and hypoxic conditions, followed by a pulse of reoxygenation for 4 h.

resultsProliferation, spheroid-formation and colony formation ability under varying O

conclusionOur data suggest that when investigating CTCs as a prognostic biomarker in NSCLC, it is also essential to take into consideration EMT status to obtain a comprehensive overview of CTCs in circulation.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsNeoplastic Cells, CirculatingBiomarkersBiomarkers, TumorCell LineCell Line, TumorEpithelial-Mesenchymal TransitionErbB ReceptorsHumansHypoxiaKeratinsOxygenRNA, MessengerTumor MicroenvironmentVimentinBiomarkersBiomarkers, TumorErbB ReceptorsKeratinsOxygenRNA, MessengerVimentinCirculating tumour cellEpithelial-mesenchymal transitionHypoxiaNon-small cell lung cancerRare cellsReoxygenation

Identifiers

PMID35932303
PMCPMC9587087
OpenAlexW4290072685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.