Evidence map›Paper›PMID 35932279›Full record

ArticleJournal of the American Geriatrics Society2022

Effect of the STRIDE fall injury prevention intervention on falls, fall injuries, and health-related quality of life.

David A Ganz, Anita H Yuan, Erich J Greene, Nancy K Latham, Katy Araujo, Albert L Siu, Jay Magaziner, Jerry H Gurwitz, Albert W Wu, Neil B Alexander and 20 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02475850 (Randomized Trial of a Multifactorial Fall Injury Prevention Strategy), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02475850 phase3completednot on this map

Randomized Trial of a Multifactorial Fall Injury Prevention Strategy

TypeinterventionalSponsorBrigham and Women's HospitalRan2015 to 2020Enrolled5,451ConditionsAccidental Falls, Wounds and InjuriesArmsEvidence-based tailored fall prevention, Usual care
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. A meta-analysis of previous falls and subsequent fracture risk in cohort studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Pooled it
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  9. Validation of a Rule-Based ICD-10-CM Algorithm to Detect Fall Injuries in Medicare Data.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
  10. Article
  11. Prevalent falls, fall frequencies and health-related quality of life among community-dwelling older Chinese adults.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 15 institutions in 1 country.

David A GanzDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Anita H YuanDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Erich J GreeneYale Center for Analytical Sciences, Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.ORCID 0000-0002-9473-830X
Nancy K LathamBoston Claude D. Pepper Older Americans Independence Center, Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Katy AraujoYale Claude D. Pepper Older Americans Independence Center, Yale University, New Haven, Connecticut, USA.
Albert L SiuIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Jay MagazinerUniversity of Maryland School of Medicine, Baltimore, Maryland, USA.
Jerry H GurwitzMeyers Health Care Institute, A Joint Endeavor of Reliant Medical Group, Fallon Health, and UMass Chan Medical School, Worcester, Massachusetts, USA.
Albert W WuJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Neil B AlexanderUniversity of Michigan; Geriatric Research Education and Clinical Center, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.
Robert B WallaceUniversity of Iowa, Iowa City, Iowa, USA.
Susan L GreenspanPittsburgh Claude D. Pepper Older Americans Independence Center, Division of Geriatrics and Gerontology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jeremy RichHealthCare Partners Institute for Applied Research and Education, El Segundo, California, USA.
Elena VolpiUniversity of Texas Medical Branch Claude D. Pepper Older Americans Independence Center; Sealy Center on Aging, The University of Texas Medical Branch, Galveston, Texas, USA.
Stephen C WaringEssentia Institute of Rural Health, Essentia Health, Duluth, Minnesota, USA.ORCID 0000-0002-9674-0083
Patricia C DykesBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Fred KoIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Neil M ResnickPittsburgh Claude D. Pepper Older Americans Independence Center, Division of Geriatrics and Gerontology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Siobhan K McMahonSchool of Nursing, University of Minnesota, Minneapolis, Minnesota, USA.
Shehzad BasariaBoston Claude D. Pepper Older Americans Independence Center, Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Rixin WangYale Center for Medical Informatics, New Haven, Connecticut, USA.
Charles LuYale Center for Medical Informatics, New Haven, Connecticut, USA.
Denise EssermanYale Center for Analytical Sciences, Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.
James DziuraYale Center for Analytical Sciences, Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.
Michael E MillerWake Forest University, School of Medicine, Winston-Salem, North Carolina, USA.
Thomas G TravisonBoston Claude D. Pepper Older Americans Independence Center, Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Peter PeduzziYale Center for Analytical Sciences, Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.
Shalender BhasinBoston Claude D. Pepper Older Americans Independence Center, Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
David B ReubenDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Thomas M GillYale Claude D. Pepper Older Americans Independence Center, Yale University, New Haven, Connecticut, USA.
Brigham and Women's Hospital · USUniversity of California, Los Angeles · USGeriatric Research Education and Clinical Center · USUniversity of Pittsburgh · USYale University · USEssentia Health · USHealthCare Partners Institute for Applied Research and Education · USJohns Hopkins University · USThe University of Texas Medical Branch at Galveston · USUniversity of Iowa · USUniversity of Maryland, Baltimore · USUniversity of Massachusetts Chan Medical School · USUniversity of Michigan · USUniversity of Minnesota · USWake Forest University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Lauren Ferrante · 2002 to 2026
$37.9M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Randomized Trial of a Multifactorial Fall Injury Prevention Strategy-SupplementU01AG048270 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BHASIN, SHALENDER, GILL, THOMAS MICHAEL · 2014 to 2019
$34.8M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lona Mody, RAYMOND L YUNG · 2004 to 2026
$29.2M
University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
UTMB OAIC Research Education Component (REC)P30AG024832 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI JAMES S. GOODWIN, MD, MELISSA M. MORROW · 2005 to 2026
$26.7M
TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEWIS LIPSITZ · 2008 to 2026
$23.9M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)KL2TR000113 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$5.4M
NCATS NIH HHS KL2 TR000113NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR001863NIA NIH HHS P30 AG021342NIA NIH HHS P30 AG024824NIA NIH HHS P30 AG024827NIA NIH HHS P30 AG024832NIA NIH HHS P30 AG028747NIA NIH HHS P30 AG031679NIA NIH HHS U01 AG048270Patient-Centered Outcomes Research Institute
6 · The paper itself

Abstract

backgroundFalls are common in older adults and can lead to severe injuries. The Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) trial cluster-randomized 86 primary care practices across 10 health systems to a multifactorial intervention to prevent fall injuries, delivered by registered nurses trained as falls care managers, or enhanced usual care. STRIDE enrolled 5451 community-dwelling older adults age ≥70 at increased fall injury risk.

methodsWe assessed fall-related outcomes via telephone interviews of participants (or proxies) every 4 months. At baseline, 12 and 24 months, we assessed health-related quality of life (HRQOL) using the EQ-5D-5L and EQ-VAS. We used Poisson models to assess intervention effects on falls, fall-related fractures, fall injuries leading to hospital admission, and fall injuries leading to medical attention. We used hierarchical longitudinal linear models to assess HRQOL.

resultsFor recurrent event models, intervention versus control incidence rate ratios were 0.97 (95% confidence interval [CI], 0.93-1.00; p = 0.048) for falls, 0.93 (95% CI, 0.80-1.08; p = 0.337) for self-reported fractures, 0.89 (95% CI, 0.73-1.07; p = 0.205) for adjudicated fractures, 0.91 (95% CI, 0.77-1.07; p = 0.263) for falls leading to hospital admission, and 0.97 (95% CI, 0.89-1.06; p = 0.477) for falls leading to medical attention. Similar effect sizes (non-significant) were obtained for dichotomous outcomes (e.g., participants with ≥1 events). The difference in least square mean change over time in EQ-5D-5L (intervention minus control) was 0.009 (95% CI, -0.002 to 0.019; p = 0.106) at 12 months and 0.005 (95% CI, -0.006 to 0.015; p = 0.384) at 24 months.

conclusionsAcross a standard set of outcomes typically reported in fall prevention studies, we observed modest improvements, one of which was statistically significant. Future work should focus on patient-, practice-, and organization-level operational strategies to increase the real-world effectiveness of interventions, and improving the ability to detect small but potentially meaningful clinical effects. CLINICALTRIALS: gov identifier: NCT02475850.

Indexed as

Fractures, BoneQuality of LifeAgedHospitalizationHumansIndependent Livingcare managementfallshealth-related quality of lifeolder personspragmatic trials

Identifiers

PMID35932279
PMCPMC9669115
OpenAlexW4290068831

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.