Evidence map›Paper›PMID 35932160›Full record

ArticleInternational journal of immunopathology and pharmacology

Identification of heterogeneous subsets of aortic interleukin-17A-expressing CD4

Guizhen Lin, Lei Zhang, Zheng Yan, Wei Jiang, Beibei Wu, Dongsheng Li, Xiaofang Xiong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Guizhen LinThe Department of Cardiology at Wuhan Third Hospital, Tongren Hospital of Wuhan University, Hubei Province, China.
Lei ZhangThe Department of Cardiology at Wuhan Third Hospital, Tongren Hospital of Wuhan University, Hubei Province, China.
Zheng YanThe Department of Cardiology at Wuhan Third Hospital, Tongren Hospital of Wuhan University, Hubei Province, China.
Wei JiangThe Department of Cardiology at Wuhan Third Hospital, Tongren Hospital of Wuhan University, Hubei Province, China.
Beibei WuThe Department of Cardiology at Wuhan Third Hospital, Tongren Hospital of Wuhan University, Hubei Province, China.
Dongsheng LiThe Department of Cardiology at Wuhan Third Hospital, Tongren Hospital of Wuhan University, Hubei Province, China.
Xiaofang XiongThe Department of Cardiology at Wuhan Third Hospital, Tongren Hospital of Wuhan University, Hubei Province, China.ORCID https://orcid.org/0000-0001-9039-5576
Tongren Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesT helper 17 (Th17) cells are involved in the inflammatory response of atherosclerosis. However, their heterogeneity in the atherosclerotic aorta remains elusive. This study was designed to identify aortic Th17 subsets.

methodsThe surface markers and transcription factors of aortic interleukin-17A (IL-17A)-expressing T cells were determined by flow cytometry in an ApoE-deficient mouse atherosclerotic model. Viable aortic IL-17A-expressing T cell subsets were isolated by flow cytometry on the basis of surface markers, followed by characterizing their transcription factors by either flow cytometry or real-time RT-PCR. The effect of aortic IL-17A-expressing T cell subsets on aortic endothelial cells was determined in vitro.

resultsC-X-C Motif Chemokine Receptor 3 (CXCR3), interleukin-17 receptor E (IL-17RE), CD200, and C-C Motif Chemokine Receptor 4 (CCR4) marked three subsets of aortic IL-17A-expressing T cells: CXCR3

conclusionIL-17A-expressing CD4

Indexed as

AtherosclerosisInterleukin-17AnimalsAortaDisease Models, AnimalEndothelial CellsInterferon-gammaLigandsMiceReceptors, ChemokineTh17 CellsTranscription FactorsInterferon-gammaInterleukin-17LigandsReceptors, ChemokineTranscription FactorsaortaAtherosclerosisheterogeneityinflammationT helper 17 cells

Identifiers

PMID35932160
PMCPMC9364180
OpenAlexW4289981644

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.