ArticleParasites & vectors2022
Geographic distribution of the V1016G knockdown resistance mutation in Aedes albopictus: a warning bell for Europe.
Article in Parasites & vectors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 34 citations in OpenAlex.
- Emerging and regionally novel voltage-gated sodium channel mutations associated with pyrethroid resistance and altered binding affinity in Aedes albopictus (Skuse) from Northern Peninsular Malaysia.Parasites & vectors · 2026Article
- Metabolic resistance of the tiger mosquito to pyrethroid insecticides in La Réunion Island likely results from local adaptation.Genome biology and evolution · 2026Article
- Present and Future of Mosquito-Borne Disease Control in Europe with a Specific Focus on the Mediterranean.Insects · 2026Review
- TrackingGigaByte (Hong Kong, China) · 2026Article
- Tracking pyrethroid resistance in arbovirus mosquito vectors: mutations I1532T and F1534C in Aedes albopictus across Europe.Parasites & vectors · 2025Article
- Pyrethroid and organochlorine susceptibility in Aedes aegypti populations from eastern black sea region, Türkiye: traces in the kdr gene region of the species origin.Parasitology research · 2025Article
- Rapid-Response Vector Surveillance and Emergency Control During the Largest West Nile Virus Outbreak in Southern Spain.Insects · 2025Article
- Population Structure of the Invasive Asian Tiger Mosquito,Ecology and evolution · 2025Article
- Omics Approaches in Understanding Insecticide Resistance in Mosquito Vectors.International journal of molecular sciences · 2025Review
- Beauveria bassiana associated with a novel biomimetic hydrogel to control Aedes albopictus through lure and kill ovitraps.Pest management science · 2025Article
- Consequences of insecticide overuse in Hungary: assessment of pyrethroid resistance in Culex pipiens and Aedes albopictus mosquitoes.Parasites & vectors · 2025Article
- Multiplexed amplicon sequencing reveals the heterogeneous spatial distribution of pyrethroid resistance mutations in Aedes albopictus mosquito populations in southern France.Parasites & vectors · 2024Article
- Article
- Diversity and distribution of sodium channel mutations in Aedes albopictus (Diptera: Culicidae).Journal of medical entomology · 2024Article
- Molecular monitoring of insecticide resistance in major disease vectors in Armenia.Parasites & vectors · 2024Article
- Sterile Insect Technique (SIT) field trial targeting the suppression of Aedes albopictus in Greece.Parasite (Paris, France) · 2024Article
- High frequency of Voltage-gated sodium channel (VGSC) gene mutations in Aedes albopictus (Diptera: Culicidae) suggest rapid insecticide resistance evolution in Shanghai, China.PLoS neglected tropical diseases · 2023Article
- MosChito rafts as a promising biocontrol tool against larvae of the common house mosquito, Culex pipiens.PloS one · 2023Article
- Efficacy Evaluation of Oregano Essential Oil Mixed withInsects · 2022Article
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Authors and funding
41 authors at 20 institutions in 16 countries.
Funding
Abstract
backgroundColonization of large part of Europe by the Asian tiger mosquito Aedes albopictus is causing autochthonous transmission of chikungunya and dengue exotic arboviruses. While pyrethroids are recommended only to reduce/limit transmission, they are widely implemented to reduce biting nuisance and to control agricultural pests, increasing the risk of insurgence of resistance mechanisms. Worryingly, pyrethroid resistance (with mortality < 70%) was recently reported in Ae. albopictus populations from Italy and Spain and associated with the V1016G point mutation in the voltage-sensitive sodium channel gene conferring knockdown resistance (kdr). Genotyping pyrethroid resistance-associated kdr mutations in field mosquito samples represents a powerful approach to detect early signs of resistance without the need for carrying out phenotypic bioassays which require availability of live mosquitoes, dedicated facilities and appropriate expertise.
methodsHere we report results on the PCR-genotyping of the V1016G mutation in 2530 Ae. albopictus specimens from 69 sampling sites in 19 European countries.
resultsThe mutation was identified in 12 sites from nine countries (with allele frequencies ranging from 1 to 8%), mostly distributed in two geographical clusters. The western cluster includes Mediterranean coastal sites from Italy, France and Malta as well as single sites from both Spain and Switzerland. The eastern cluster includes sites on both sides of the Black Sea in Bulgaria, Turkey and Georgia as well as one site from Romania. These results are consistent with genomic data showing high connectivity and close genetic relationship among West European populations and a major barrier to gene flow between West European and Balkan populations.
conclusionsThe results of this first effort to map kdr mutations in Ae. albopictus on a continental scale show a widespread presence of the V1016G allele in Europe, although at lower frequencies than those previously reported from Italy. This represents a wake-up call for mosquito surveillance programs in Europe to include PCR-genotyping of pyrethroid resistance alleles, as well as phenotypic resistance assessments, in their routine activities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.