ArticleCritical care (London, England)2022
Time-varying intensity of oxygen exposure is associated with mortality in critically ill patients with mechanical ventilation.
Article in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- The Incidence, Risk Factors, and Hospital Mortality of Prolonged Mechanical Ventilation among Cardiac Surgery Patients: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2024Pooled it
- Closed-loop automated oxygen control in late preterm and term, ventilated infants: A randomised controlled trial.Acta paediatrica (Oslo, Norway : 1992) · 2025Trial
- Oxygen physiology and mechanisms of oxygen toxicity: a narrative review.Medical gas research · 2026Review
- Article
- Time-weighted urine oxygen tension as a predictor of acute kidney injury in patients with sepsis: a preliminary prospective observational study.Renal failure · 2025Observational
- OPTIMAL PAO 2 IS 130-160 MMHG IN THE FIRST WEEK FOR SEPSIS PATIENTS IN ICU: A RETROSPECTIVE COHORT STUDY BASED ON MIMIC-IV DATABASE.Shock (Augusta, Ga.) · 2025Article
- Association between glucose-to-lymphocyte ratio and long-term mortality among women after coronary artery bypass grafting: filling gaps in female.BMC cardiovascular disorders · 2025Article
- Association Between Early Hyperoxemia Exposure and Intensive Care Unit Mortality in Intracerebral Hemorrhage: An Observational Cohort Analysis.Neurocritical care · 2024Observational
- U-shaped association between serum calcium and in-hospital mortality in patients with congestive heart failure.ESC heart failure · 2024Observational
- Mortality rate analysis of patients on invasive mechanical ventilation in the intensive care unit on day 28.Biomedical reports · 2024Article
- The neutrophil-to-lymphocyte ratio levels over time correlate to all-cause hospital mortality in sepsis.Heliyon · 2024Article
- Clinical phenotypes and short-term outcomes based on prehospital point-of-care testing and on-scene vital signs.NPJ digital medicine · 2024Article
- The association between frailty and the risk of mortality in critically ill congestive heart failure patients: findings from the MIMIC-IV database.Frontiers in endocrinology · 2024Article
- The prognostic nutritional index predicts all-cause mortality in critically ill patients with acute myocardial infarction.BMC cardiovascular disorders · 2023Article
- The association of diastolic arterial pressure and heart rate with mortality in septic shock: a retrospective cohort study.European journal of medical research · 2022Article
- Early hyperoxia and 28-day mortality in patients on venoarterial ECMO support for refractory cardiogenic shock: discussion about potential confounding factors.Critical care (London, England) · 2022Article
- Frailty index based on laboratory tests improves prediction of short-and long-term mortality in patients with critical acute myocardial infarction.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThere is no consensus exists regarding the association between oxygen exposure (arterial oxygen tension or fraction of inspired oxygen) and outcomes for patients with mechanical ventilation. Additionally, whether the association remains persistent over time is unknown. We aimed to explore the association between exposure to different intensities of oxygen exposure over time and 28-day mortality in patients with mechanical ventilation.
methodsWe obtained data from the Medical Information Mart for Intensive Care IV (MIMIC-IV), which included adult (≥ 18 years) patients who received invasive mechanical ventilation for at least 48 h. We excluded patients who received extracorporeal membrane oxygenation (ECMO) or who initiated ventilation more than 24 h after ICU admission. The primary outcome was 28-day mortality. Piece-wise exponential additive mixed models were employed to estimate the strength of associations over time.
resultsA total of 7784 patients were included in the final analysis. Patients had a median duration of invasive mechanical ventilation of 8.1 days (IQR: 3.8-28 days), and the overall 28-day mortality rate was 26.3%. After adjustment for baseline and time-dependent confounders, both daily time-weighted average (TWA) arterial oxygen tension (PaO
conclusionPaO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.