Evidence map›Paper›PMID 35931989›Full record

Trial reportBMC anesthesiology2022

Low-dose dexmedetomidine as a perineural adjuvant for postoperative analgesia: a randomized controlled trial.

Wei Liu, Jingwen Guo, Jun Zheng, Bin Zheng, Xiangcai Ruan, Addition of Dexmedetomidine to Ropivacaine-Induced supraclavicular Block (ADRIB) investigator

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02630290 (Addition of Dexmedetomidine to Ropivacaine-induced Supraclavicular Plexus Block, a Randomized Controlled Study), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02630290 phase4completednot on this map

Addition of Dexmedetomidine to Ropivacaine-induced Supraclavicular Plexus Block, a Randomized Controlled Study

TypeinterventionalSponsorGuangzhou First People's HospitalRan2015 to 2016Enrolled60ConditionsRadius Fractures, Ulna Fractures, Hand Injuries, Wrist InjuriesArmsRopivacaine, Ropivacaine + Dexmedetomidine
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wei LiuDepartment of Anesthesiology, School of Medicine, the Second Affiliated Hospital, South China University of Technology, Guangzhou, 510180, People's Republic of China.
Jingwen GuoDepartment of Anesthesiology, School of Medicine, the Second Affiliated Hospital, South China University of Technology, Guangzhou, 510180, People's Republic of China.
Jun ZhengDepartment of Anesthesiology, School of Medicine, the Second Affiliated Hospital, South China University of Technology, Guangzhou, 510180, People's Republic of China.
Bin ZhengDepartment of Anesthesiology, School of Medicine, the Second Affiliated Hospital, South China University of Technology, Guangzhou, 510180, People's Republic of China.
Xiangcai RuanDepartment of Anesthesiology and Pain Medicine, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510665, China. ruanxc@mail.sysu.edu.cn.
Addition of Dexmedetomidine to Ropivacaine-Induced supraclavicular Block (ADRIB) investigator
South China University of Technology · CNSixth Affiliated Hospital of Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDexmedetomidine has been proposed as an additive to local anesthetics to prolong peripheral nerve block duration; however, perineural dexmedetomidine has been associated with an increased risk of bradycardia and hypotension This randomized controlled study investigated the effects of low-dose dexmedetomidine as a perineural adjuvant for postoperative analgesia.

methodsFifty-five patients who had undergone elective upper extremity surgery were randomized to receive an ultrasound-guided supraclavicular brachial plexus block with 20 mL 0.5% ropivacaine with or without 30 μg dexmedetomidine. The primary outcome was the duration of analgesia. Secondary outcomes included the onset time and duration of the motor and sensory blocks, incidence of hypotension and bradycardia, total postoperative analgesics, and safety assessment during the 24 h after surgery.

resultsDexmedetomidine significantly prolonged the duration of analgesia (887 ± 92 min vs 661 ± 83 min, P < 0.0001). The onset time and the duration of motor and sensory block were significantly different between the groups (all P < 0.001). No episodes of hypotension or bradycardia were detected in the dexmedetomidine group. The total postoperative analgesic use and side effect profiles in the first 24 h postoperative period were similar for both groups.

conclusionsLow-dose dexmedetomidine (30 μg) as a perineural adjuvant significantly prolonged the analgesic duration of a brachial plexus block without inducing hemodynamic instability.

trial registrationThis trial was registered at ClinicalTrial.gov (NCT02630290).

Indexed as

AnalgesiaBrachial Plexus BlockDexmedetomidineHypotensionAnesthetics, LocalBradycardiaHumansAnesthetics, LocalDexmedetomidineDexmedetomidineNerve blockPostoperative pain

Identifiers

PMID35931989
PMCPMC9354301
OpenAlexW4289860813

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.