Evidence map›Paper›PMID 35931963›Full record

ArticleBMC nephrology2022

Chronic kidney disease of nontraditional causes in central Panama.

Karen Courville, Norman Bustamante, Bárbara Hurtado, Maydelin Pecchio, Clarissa Rodríguez, Virginia Núñez-Samudio, Iván Landires

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In one paragraph

Article in BMC nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Karen Courville *Instituto de Ciencias Médicas, PO Box 0710-00043, Las Tablas, Los Santos, Panamá.
Norman Bustamante *Instituto de Ciencias Médicas, PO Box 0710-00043, Las Tablas, Los Santos, Panamá.
Bárbara HurtadoDepartamento de Epidemiología, Hospital Dr. Gustavo N. Collado, Caja de Seguro Social, Chitré, Herrera, Panamá.
Maydelin PecchioInstituto de Ciencias Médicas, PO Box 0710-00043, Las Tablas, Los Santos, Panamá.
Clarissa RodríguezDepartamento de Infecciones Nosocomiales, Hospital Dr. Gustavo N. Collado, Caja de Seguro Social, Chitré, Herrera, Panamá.
Virginia Núñez-Samudio *Instituto de Ciencias Médicas, PO Box 0710-00043, Las Tablas, Los Santos, Panamá. vnunez@institutodecienciasmedicas.org.
Iván Landires *Instituto de Ciencias Médicas, PO Box 0710-00043, Las Tablas, Los Santos, Panamá. ilandires@institutodecienciasmedicas.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOver the last three decades, the mesoamerican region has seen an increase in the frequency of patients diagnosed with Chronic Kidney Disease of nontraditional causes (CKDnt) also known as Meso-American Nephropathy (MeN). A region with an increased frequency of patients with Chronic Kidney Disease (CKD) has been identified in central Panama. The present study aims to characterize the clinical presentation of patients with CKDnt in an understudied population of the central region of Panama and to compare them with patients with traditional chronic kidney disease (CKDt).

methodsA retrospective descriptive study was conducted in a nephrology reference hospital in the central provinces of Herrera and Los Santos, comparing a group of 15 patients with CKDnt to 91 patients with CKDt. Sociodemographic variables, personal history, laboratory parameters, and of renal ultrasound were compared.

resultsPatients with CKDnt had a median age of 58 years (IQR: 52-61), significantly lower (P < 0.001) than patients with CKDt with a median age of 71 years (IQR: 64-78). Patients with CKDnt had a history of being agricultural (60%) and transportation (20%) workers, significantly higher than patients with CKDt (15%, P < 0.001 and 0%, P < 0.01 respectively). Renal atrophy and hyperuricemia are significant clinical markers of CKDnt (P < 0.001 and P < 0.05 respectively).

conclusionTo our knowledge, this is the first study in Panama to investigate the clinical presentation of patients with CKDnt and one of the few in Central America and the world that compares them with patients with CKDt. In central Panama the typical CKDnt patient is a male in his 50 s who is primarily engaged in agriculture or as a public transport driver. Renal atrophy and hyperuricemia are significant clinical markers of CKDnt. Further studies are needed to help understand the common determinants and risk factors for CKDnt development in Panama and Mesoamerica.

Indexed as

HyperuricemiaRenal Insufficiency, ChronicAgedAtrophyBiomarkersHumansMaleMiddle AgedPanamaRetrospective StudiesBiomarkersChronic kidney diseaseClinical presentationMesoamerican nephropathyNontraditionalPanamaTraditional

Identifiers

PMID35931963
PMCPMC9356394

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.