ArticleBMC geriatrics2022
Life-space, frailty, and health-related quality of life.
Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Mapping Research Trends in Frailty and Nutrition: A Combined Bibliometric and Structured Review (2000-2024).Nutrients · 2025Pooled it
- Patient self-reported outcomes 10 years after surgical correction in AIS patients. A systematic review and meta-analysis.Archives of orthopaedic and trauma surgery · 2025Pooled it
- Goals of Frail Older People Living With Chronic Kidney Disease: A Mixed Methods Study.Journal of the American Geriatrics Society · 2025Trial
- Life-Space Mobility in Heart Failure With Preserved Ejection Fraction.Journal of cardiac failure - intersections · 2026Article
- Integrating GPS and Accelerometry to Capture Life-Space Mobility in Parkinson's Disease.Sensors (Basel, Switzerland) · 2026Article
- Frailty and quality of life in older ICU survivors: a scoping review of assessment tools and methodologies.BMC geriatrics · 2026Article
- Associations of external environment with life-space mobility among community-dwelling older adults: the potential mediating role of intrinsic capacity.BMC geriatrics · 2026Article
- Article
- Demographic, Environmental and Clinical Factors Associated with Life-Space Mobility Among Community-Dwelling Older Adults with Cardiovascular Disease: Findings from the International Mobility in Aging Study (IMIAS).Clinical interventions in aging · 2026Article
- In a prospective population-based study, the degree of mobility impairment during hospitalisation is associated with higher degrees of frailty.Aging clinical and experimental research · 2025Article
- Association between urbanization levels and frailty among middle-aged and older adults in China: evidence from the CHARLS.BMC medicine · 2025Article
- Baseline Characteristics of Frailty and Disease Stage in Older People Living With CKD.Kidney international reports · 2025Article
- The impact of frailty on quality of life among older adults in nursing homes: the mediating role of psychological resilience.Frontiers in public health · 2025Article
- The dynamic relationship between the life-space mobility and family resilience of older adult patients with chronic heart failure.Frontiers in public health · 2025Article
- Association of metabolic syndrome severity with frailty progression among Chinese middle and old-aged adults: a longitudinal study.Cardiovascular diabetology · 2024Article
- Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures.Nature aging · 2023Article
- Causal association between air pollution and frailty: a Mendelian randomization study.Frontiers in public health · 2023Article
- A review of frailty instruments in human medicine and proposal of a frailty instrument for dogs.Frontiers in veterinary science · 2023Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionLife-space and frailty are closely linked to health-related quality of life and understanding their inter-relationship could indicate potential intervention targets for improving quality of life. We set out to examine the relationship between frailty and life-space and their relative impact on quality of life measures.
methodsUsing cross-sectional data from a population-representative cohort of people aged ≥ 70 years, we assessed quality of life with the EuroQol Health Index tool (5-levels) (EQ-5D-5L). We also undertook a life-space assessment and derived a frailty index. Linear regression models estimated EQ-5D-5L scores (dependent variable) using life-space assessment, frailty index and interactions between them. All models were adjusted by age, sex, lifestyle, and social care factors.
resultsA higher EQ-5D Index was associated with higher life-space (0.02 per life-space assessment score, 95%CI: 0.01 to 0.03, p < 0.01) and decreasing frailty (-0.1 per SD, 95%CI: -0.1 to -0.1, p < 0.01). There was evidence of an interaction between life-space and frailty, where the steepest gradient for life-space and EQ-5D was in those with the highest frailty (interaction term = 0.02 per SD of frailty, 95%CI: 0.01 to 0.03, p < 0.01).
conclusionIndividuals with the highest frailty were twice as likely to have higher quality of life in association with a larger life-space. Interventions designed to improve quality of life in frail older people could focus on increasing a person's life-space.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.