Evidence map›Paper›PMID 35931947›Full record

ArticleBMC cardiovascular disorders2022

Statins are associated with reduced likelihood of sarcopenia in a sample of heart failure outpatients: a cross-sectional study.

Rui Valdiviesso, Ana Rita Sousa-Santos, Luís F Azevedo, Emília Moreira, Teresa F Amaral, José Silva-Cardoso, Nuno Borges

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  7. Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia.Journal of cachexia, sarcopenia and muscle · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rui ValdiviessoFCNAUP - Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto, Rua do Campo Alegre, 823, 4150-180, Porto, Portugal. valdiviesso@gmail.com.
Ana Rita Sousa-SantosFCNAUP - Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto, Rua do Campo Alegre, 823, 4150-180, Porto, Portugal.
Luís F AzevedoCINTESIS - Centro de Investigação em Tecnologias e Serviços de Saúde, R. Dr. Plácido da Costa, s/n, ed. Nascente, piso 2, 4200-450, Porto, Portugal.
Emília MoreiraCINTESIS - Centro de Investigação em Tecnologias e Serviços de Saúde, R. Dr. Plácido da Costa, s/n, ed. Nascente, piso 2, 4200-450, Porto, Portugal.
Teresa F AmaralFCNAUP - Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto, Rua do Campo Alegre, 823, 4150-180, Porto, Portugal.
José Silva-CardosoCINTESIS - Centro de Investigação em Tecnologias e Serviços de Saúde, R. Dr. Plácido da Costa, s/n, ed. Nascente, piso 2, 4200-450, Porto, Portugal.
Nuno BorgesFCNAUP - Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto, Rua do Campo Alegre, 823, 4150-180, Porto, Portugal.
Universidade do Porto · PTCentre for Health Technology and Services Research · PTAdministração Regional de Saúde de Lisboa e Vale do Tejo · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcopenia is prevalent in heart failure (HF) patients, contributing to its poor prognosis. Statin use is postulated as a probable risk for developing sarcopenia, but little is known regarding this association in HF patients. This work aims at classifying and characterising sarcopenia and at describing the association of statin use with sarcopenia in a sample of Portuguese HF outpatients.

methodsIn this cross-sectional study, a sample of 136 HF patients (median age: 59 years, 33.8% women) was recruited from an HF outpatients' clinic of a University Hospital in Portugal. Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People 2. Clinical, nutritional, and dietary data were collected.

resultsA total of 25 (18.4%) individuals were categorised as sarcopenic, ranging from 12.2% in younger (< 65 years) participants vs. 30.4% in older ones and from 3.3% in men vs. 47.8% in women. Severe sarcopenia accounted for 7.4% of the sample and sarcopenic obesity was identified in 5.1% of the individuals. A total of 65.4% of the participants were statin users. In multivariable analysis (n = 132, 25 sarcopenic), the use of statins was inversely associated with sarcopenia (OR = 0.03; 95% CI = 0.01, 0.30). Each additional age year was associated with a 9% increase in the likelihood of being sarcopenic (OR = 1.09; 95% CI = 1.01, 1.17), and each Kg.m

conclusionsContrary to what was expected, patients medicated with statins were less likely to be sarcopenic. Although this finding deserves further research, we hypothesise that this might be related to the pleiotropic effects of statins on endothelial function, contributing to better neuromuscular fitness.

Indexed as

Heart FailureHydroxymethylglutaryl-CoA Reductase InhibitorsSarcopeniaAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedOutpatientsHydroxymethylglutaryl-CoA Reductase InhibitorsEndothelial dysfunctionHeart failureNutritional statusPolypharmacySarcopeniaStatins

Identifiers

PMID35931947
PMCPMC9354359
OpenAlexW4289941112

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.