Evidence map›Paper›PMID 35931461›Full record

ArticleJournal of medical virology2022

Serosurvey in SARS-CoV-2 inactivated vaccine-elicited neutralizing antibodies against authentic SARS-CoV-2 and its viral variants.

Lirong Zou, Huan Zhang, Zhonghua Zheng, Yushan Jiang, Yushi Huang, Shujian Lin, Jianxiang Yu, Xiaoling Deng, Jianfeng He, Chenguang Shen and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Observational
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lirong ZouInstitute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.
Huan ZhangInstitute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.
Zhonghua ZhengInstitute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.
Yushan JiangBSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Yushi HuangInstitute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.
Shujian LinInstitute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.
Jianxiang YuInstitute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.
Xiaoling DengInstitute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.
Jianfeng HeInstitute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.
Chenguang ShenBSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.ORCID 0000-0001-8607-3750
Baisheng LiInstitute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.
Institute of Microbiology · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been emerging and circulating in different parts of the world. Millions of vaccine doses have been administered globally, which reduces the morbidity and mortality of coronavirus disease-2019 efficiently. Here, we assess the immune responses of individuals after two shots of BBIBP-CorV or CoronaVac inactivated vaccine. We measured neutralizing antibody responses after the second vaccination by using authentic SARS-CoV-2 and its viral variants. All the serum samples efficiently neutralized SARS-CoV-2 wild-type lineage, in contrast, a part of serum samples failed to neutralize Alpha, Beta, Gamma, Delta, or Eta lineages, and only several serum samples were able to neutralize Omicron lineage virus strains (BA.1 and BA.2) with low neutralization titer. As compared with the neutralization of SARS-CoV-2 wild-type lineage, the neutralization of all other SARS-CoV-2 variant lineages was significantly lower. Considering that all the SARS-CoV-2 mutation viruses challenged the antibody neutralization induced by BBIBP-CorV and CoronaVac, it is necessary to carry out a third booster vaccination to increase the humoral immune response against the SARS-CoV-2 mutation viruses.

Indexed as

COVID-19Viral VaccinesAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesHumansSARS-CoV-2Vaccines, InactivatedAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesSARS-CoV-2 inactivated vaccinesVaccines, InactivatedViral Vaccinesimmune responseinactivated vaccineneutralizing antibodiesSARS-CoV-2viral variants

Identifiers

PMID35931461
PMCPMC9538410
OpenAlexW4289917850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.