ArticleMolecular cell2022
S-nitrosylation is required for β
Open access · greenAbstract read
In one paragraph
Article in Molecular cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Inhaled S-nitrosoglutathione in asthma: Airway SCoR2 expression and determinants of human bronchodilator response.The Journal of allergy and clinical immunology · 2026Article
- Estrogen Induced Regulation of Mucosal-Associated Invariant T Cells in Asthma.Journal of immunology research · 2026Article
- Biased Orthosteric Agonism and Allosteric Modulation: Emerging Strategies for Developing New Class of β-Agonists for Obstructive Airway Diseases.American journal of respiratory cell and molecular biology · 2025Review
- S-nitrosylation of pVHL regulates βProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course.American journal of respiratory and critical care medicine · 2024Review
- ROS-mediated regulation of β2AR function: Does oxidation play a meaningful role towards β2-agonist tachyphylaxis in airway obstructive diseases?Biochemical pharmacology · 2024Review
- Paradoxical bronchodilator response is associated with increased risk of asthma exacerbations.The journal of allergy and clinical immunology. In practice · 2024Article
- Adrenoceptor Desensitization: Current Understanding of Mechanisms.Pharmacological reviews · 2024Review
- Reactive Oxygen Species Behaving Badly: Oxidized Phosphatidylcholines Corrupt CaAmerican journal of respiratory cell and molecular biology · 2023Article
- The role of G protein-coupled receptor in neutrophil dysfunction during sepsis-induced acute respiratory distress syndrome.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Fabio V FonsecaInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Thomas M RaffayDepartment of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Kunhong XiaoDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Precious J McLaughlinInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Zhaoxia QianInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Zachary W GrimmettInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Naoko AdachiInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Benlian WangCenter for Proteomics and Bioinformatics, Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Alfred HausladenInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Brian A CobbDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Rongli ZhangCardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Douglas T HessInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Benjamin GastonDepartment of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Nevin A LambertDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
James D ReynoldsInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Richard T PremontInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Jonathan S StamlerInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA. Electronic address: jss156@case.edu.
Case Western Reserve University · USAugusta University · USDuke University · USUniversity School · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4MRegulation of Beta-Adrenergic Receptor Signaling by S-NitrosylationP01HL075443 · NHLBI · DUKE UNIVERSITY · PI XIAO, KUNHONG · 2004 to 2019
$26.1MProject 3 - Personalized cystic fibrosis treatment strategies with synergistic therapies Identified in vitro.P01HL128192 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN · 2016 to 2020
$12.2MS-nitrosylation signaling in asthmaP01HL158507 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LAHM, TIM · 2021 to 2025
$12.0MRestoration and Function of S-Nitrosothiol in Stored BloodR01HL126900 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JONATHAN S. STAMLER · 2016 to 2026
$5.0MNovel Regulation of Renal Function by S-NitrosylationR01DK119506 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI JONATHAN S. STAMLER, Hualin Zhou · 2018 to 2026
$3.7MConventional and unconventional GPCR-G protein couplingR35GM145284 · NIGMS · AUGUSTA UNIVERSITY · PI Nevin Alan Lambert · 2022 to 2026
$1.8MDirect assessment of GPCR-transducer coupling and G protein subtype biasR01GM130142 · NIGMS · AUGUSTA UNIVERSITY · PI LAMBERT, NEVIN ALAN · 2018 to 2021
$1.5MNHLBI NIH HHS P01 HL075443NHLBI NIH HHS P01 HL128192NHLBI NIH HHS P01 HL158507NHLBI NIH HHS R01 HL126900NIDDK NIH HHS R01 DK119506NIGMS NIH HHS R01 GM130142NIGMS NIH HHS R35 GM145284NIGMS NIH HHS T32 GM007250
Abstract
The β
Indexed as
AsthmaAnimalsMiceSignal Transductionairway hyperreactivityasthmabeta-agonistcaveolaedesensitizationnitric oxidereceptor internalizationS-nitrosylationβ(2)-adrenergic receptor
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.