Evidence map›Paper›PMID 35931038›Full record

ArticleMolecular cell2022

Systems biochemistry to "deorphanize" human mitochondrial proteome.

Francois Miros, Ran Liu, Hongying Shen

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Francois MirosDepartment of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA; Systems Biology Institute, Yale West Campus, West Haven, CT, USA.
Ran LiuDepartment of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA; Systems Biology Institute, Yale West Campus, West Haven, CT, USA.
Hongying ShenDepartment of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA; Systems Biology Institute, Yale West Campus, West Haven, CT, USA. Electronic address: hongying.shen@yale.edu.
Yale University · US

Funding

An integrated approach to the study of mitochondrial vitamin B12 pathway and type II fatty acid synthesisR00GM124296 · NIGMS · YALE UNIVERSITY · PI SHEN, HONGYING · 2020 to 2022
$747k
NIGMS NIH HHS R00 GM124296
6 · The paper itself

Abstract

Rensvold, Shishkova, et al. (2022) apply an integrated systems biology approach spanning proteomics, lipidomics, and metabolomics to a collection of CRISPR knockout cells targeting 116 distinct human mitochondrial proteins, revealing new mitochondrial biology and guiding orphan disease diagnosis.

Indexed as

ProteomeProteomicsHumansLipidomicsMetabolomicsSystems BiologyProteome

Identifiers

PMID35931038
OpenAlexW4289779054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.