Evidence map›Paper›PMID 35930892›Full record

ArticleCortex; a journal devoted to the study of the nervous system and behavior2022

Enhanced positive emotional reactivity in frontotemporal dementia reflects left-lateralized atrophy in the temporal and frontal lobes.

Suzanne M Shdo, Ashlin R K Roy, Samir Datta, Isabel J Sible, Sladjana Lukic, David C Perry, Katherine P Rankin, Joel H Kramer, Howard J Rosen, Bruce L Miller and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Suzanne M ShdoMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; University of California, Berkeley, Department of Psychology, Berkeley, CA, USA. Electronic address: shdo@berkeley.edu.
Ashlin R K RoyMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: ashlin.roy@ucsf.edu.
Samir DattaMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: samir.datta@ucsf.edu.
Isabel J SibleMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: jsible@usc.edu.
Sladjana LukicMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: sladjana.lukic@ucsf.edu.
David C PerryMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: david.perry@ucsf.edu.
Katherine P RankinMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: katherine.rankin@ucsf.edu.
Joel H KramerMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: joel.kramer@ucsf.edu.
Howard J RosenMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: howie.rosen@ucsf.edu.
Bruce L MillerMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: bruce.miller@ucsf.edu.
William W SeeleyMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: bill.seeley@ucsf.edu.
Sarah R HolleyDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; San Francisco State University, Department of Psychology, San Francisco, CA, USA. Electronic address: sholley@sfsu.edu.
Maria L Gorno-TempiniMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: marialuisa.gornotempini@ucsf.edu.
Virginia E SturmMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: virginia.sturm@ucsf.edu.
University of California, San Francisco · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Emotion network dysfunction and decline in early frontotemporal dementiaR01AG052496 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Virginia Emily Sturm · 2017 to 2026
$6.9M
Primary Progressive Aphasia: Cognition, Anatomy and ProgressionRF1NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2022 to 2022
$4.7M
Attention and Semantic Evaluation as Predictors of Empathy in Healthy Aging and Frontotemporal DementiaRF1AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2019 to 2019
$4.0M
Neurobiological Basis of Emotion Regulation Trajectories in Early Alzheimer's DiseaseR01AG057204 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STURM, VIRGINIA EMILY · 2017 to 2021
$3.9M
Measuring Altered Social Behavior in Neurodegenerative DiseaseR01AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2008 to 2018
$3.6M
Identifying the Neural Basis and Functional Role of Emotional Empathy in DementiaK23AG040127 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STURM, VIRGINIA EMILY · 2012 to 2016
$713k
NIA NIH HHS K23 AG040127NIA NIH HHS P01 AG019724NIA NIH HHS R01 AG029577NIA NIH HHS R01 AG052496NIA NIH HHS R01 AG057204NIA NIH HHS RF1 AG029577NINDS NIH HHS RF1 NS050915
6 · The paper itself

Abstract

In frontotemporal dementia (FTD), left-lateralized atrophy patterns have been associated with elevations in certain positive emotions. Here, we investigated whether positive emotional reactivity was enhanced in semantic variant primary progressive aphasia (svPPA), an FTD syndrome that targets the left anterior temporal lobe. Sixty-one participants (16 people with svPPA, 24 people with behavioral variant FTD, and 21 healthy controls) viewed six 90-sec trials that were comprised of a series of photographs; each trial was designed to elicit a specific positive emotion, negative emotion, or no emotion. Participants rated their positive emotional experience after each trial, and their smiling behavior was coded with the Facial Action Coding System. Results indicated that positive emotional experience and smiling were elevated in svPPA in response to numerous affective and non-affective stimuli. Voxel-based morphometry analyses revealed that greater positive emotional experience and greater smiling in the patients were both associated with smaller gray matter volume in the left superior temporal gyrus (p

Indexed as

Frontotemporal DementiaPick Disease of the BrainAtrophyEmotionsFrontal LobeHumansMagnetic Resonance ImagingElationEuphoriaMoodNeurodegenerationSemantic dementia

Identifiers

PMID35930892
PMCPMC9867572
OpenAlexW4283651509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.