ArticleAge and ageing2022
New horizons in the ageing autonomic nervous system: orthostatic hypotension and supine hypertension.
Article in Age and ageing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- A Review of Clinical Trial and Meta-Analyses of BP Treatment Strategies for Patients with Orthostatic Hypotension: Blood Pressure Management in Patients with Hypertension and Orthostatic Hypotension.Current hypertension reports · 2026Pooled it
- Effect of IoC2-guided analgesic titration on intraoperative opioid consumption in older patients undergoing laparoscopic colorectal surgery: a randomized controlled trial.Journal of anesthesia · 2026Article
- Autonomic dysfunction in patients with wild-type transthyretin amyloidosis.Journal of neurology · 2026Article
- Supine hypertension and cardiovascular disease: controversies and advances.Future cardiology · 2025Review
- Sit-up test for assessing impaired blood pressure regulation in community-dwelling older adults: a cross-sectional study.BMC geriatrics · 2025Article
- Clinical validation of a wearable ultrasound sensor of blood pressure.Nature biomedical engineering · 2025Article
- The relationship between physical activity, orthostatic blood pressure reactions and subclinical atherosclerosis: the Swedish CArdioPulmonary bioImage Study (SCAPIS).Journal of human hypertension · 2025Article
- Prevalence of Sleep Apnea in Patients with Syncope of Unclear Cause: SINCOSAS Study.Medicina (Kaunas, Lithuania) · 2025Article
- Hypertension and orthostatic hypotension in the elderly: a challenging balance.The Lancet regional health. Europe · 2025Review
- Applying systems thinking to unravel the mechanisms underlying orthostatic hypotension related fall risk.GeroScience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood pressure regulation is an automatic, moment-by-moment buffering of the blood pressure in response to physiological changes such as orthostasis, exercise and haemorrhage. This finely orchestrated reflex is called the baroreflex. It is a regulated arc of afferent, central and efferent arms. Multiple physiological changes occur with ageing that can disrupt this reflex, making blood pressure regulation less effective. In addition, multiple changes can occur with ageing-related diseases such as neurodegeneration, atherosclerosis, deconditioning and polypharmacy. These changes commonly result in orthostatic hypotension, hypertension or both, and are consistently associated with multiple adverse outcomes. In this article, we discuss the healthy baroreflex, and physiological and pathophysiological reasons for impaired baroreflex function in older people. We discuss why the common clinical manifestations of orthostatic hypotension and concomitant supine hypertension occur, and strategies for balancing these conflicting priorities. Finally, we discuss strategies for treating them, outlining our practice alongside consensus and expert guidance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.