ArticleAge and ageing2022
Association of multimorbidity patterns with incident disability and recovery of independence among middle-aged and older adults.
Article in Age and ageing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Patterns of multimorbidity, their outcomes and analytical methods for their determination: a systematic review.BMC public health · 2026Pooled it
- Association of multimorbidity and its patterns with incident possible sarcopenia among middle-aged and older adults: findings from a national prospective cohort study in China.BMC musculoskeletal disorders · 2026Article
- Difficulty with taking medications and the future risk of Alzheimer's disease and related dementias: Health and Retirement Study of Americans.American journal of neurodegenerative disease · 2026Article
- Correlation of Waist Circumference-Mediated Glycosylated Hemoglobin Levels With New-Onset BADL Disability.Journal of diabetes research · 2026Article
- Caring for the "Osteo-Cardiovascular Faller": Associations between Multimorbidity and Fall Transitions among Middle-Aged and Older Chinese.Health data science · 2025Article
- Associations between sleep changes and multimorbidity patterns in middle-aged and older Chinese adults.Frontiers in public health · 2025Article
- Longitudinal study on health-related quality of life and multimorbidity: from trajectories to outcomes in China.Frontiers in public health · 2025Article
- New Disability in a Cohort Study of Older Men-The Manitoba Follow-Up Study.Canadian geriatrics journal : CGJ · 2024Article
- Patterns of the Health and Economic Burden of 33 Rare Diseases in China: Nationwide Web-Based Study.JMIR public health and surveillance · 2024Article
- Interactions between patterns of multimorbidity and functional status among hospitalized older patients: a novel approach using cluster analysis and association rule mining.Journal of translational medicine · 2024Article
- Association of handgrip strength asymmetry and weakness with functional disability among middle-aged and older adults in China.Journal of global health · 2024Article
- Trends in disability in activities of daily living and instrumental activities of daily living among Chinese older adults from 2011 to 2018.Aging clinical and experimental research · 2024Article
- Multimorbidity Patterns and Associations with Gait, Balance and Lower Extremity Muscle Function in the Elderly: A Cross-Sectional Study in Northwest China.International journal of general medicine · 2023Article
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5 authors.
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Abstract
objectiveto identify multimorbidity patterns among middle-aged and older adults in China and examine how these patterns are associated with incident disability and recovery of independence.
methodsdata were from The China Health and Retirement Longitudinal Study. We included 14,613 persons aged ≥45 years. Latent class analysis (LCA) was conducted to identify multimorbidity patterns with clinical meaningfulness. Multinomial logistic models were used to determine the adjusted association between multimorbidity patterns and incident disability and recovery of independence.
resultswe identified four multimorbidity patterns: 'low morbidity' (67.91% of the sample), 'pulmonary-digestive-rheumatic' (17.28%), 'cardiovascular-metabolic-neuro' (10.77%) and 'high morbidity' (4.04%). Compared to the 'low morbidity' group, 'high morbidity' (OR = 2.63, 95% CI = 1.97-3.51), 'pulmonary-digestive-rheumatic' (OR = 1.89, 95% CI = 1.63-2.21) and 'cardiovascular-metabolic-neuro' pattern (OR = 1.61, 95% CI = 1.31-1.97) had higher odds of incident disability in adjusted multinomial logistic models. The 'cardiovascular-metabolic-neuro' (OR = 0.60, 95% CI = 0.44-0.81), 'high morbidity' (OR = 0.68, 95% CI = 0.47-0.98) and 'pulmonary-digestive-rheumatic' group (OR = 0.75, 95% CI = 0.60-0.95) had lower odds of recovery from disability than the 'low morbidity' group. Among people without disability, the 'cardiovascular-endocrine-neuro' pattern was associated with the highest 2-year mortality (OR = 2.42, 95% CI = 1.56-3.72).
conclusionsmultimorbidity is complex and heterogeneous, but our study demonstrates that clinically meaningful patterns can be obtained using LCA. We highlight four multimorbidity patterns with differential effects on incident disability and recovery from disability. These studies suggest that targeted prevention and treatment approaches are needed for people with multimorbidity.
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