Atomic-Level View of the Functional Transition in Vertebrate Hemoglobins: The Case of Antarctic Fish Hbs.

Nicole Balasco, Antonella Paladino, Giuseppe Graziano, Marco D'Abramo, Luigi Vitagliano

Open access · hybridAbstract read

In one paragraph

Article in Journal of chemical information and modeling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Nicole BalascoInstitute of Molecular Biology and Pathology, CNR c/o Dep. Chemistry, University of Rome, Sapienza, P.le A. Moro 5, 00185 Rome, Italy.

Antonella PaladinoInstitute of Biostructures and Bioimaging, CNR, Via Pietro Castellino 111, 80131 Naples, Italy.ORCID 0000-0002-9397-1572

Giuseppe GrazianoDepartment of Science and Technology, University of Sannio, via Francesco de Sanctis snc, Benevento 82100, Italy.

Marco D'AbramoDepartment of Chemistry, University of Rome Sapienza, P.le A.Moro 5, 00185 Rome, Italy.ORCID 0000-0001-6020-8581

Luigi VitaglianoInstitute of Biostructures and Bioimaging, CNR, Via Pietro Castellino 111, 80131 Naples, Italy.

Institute of Biostructure and Bioimaging · ITInstitute of Molecular Biology and Pathology · ITSapienza University of Rome · ITUniversity of Sannio · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tetrameric hemoglobins (Hbs) are prototypal systems for studies aimed at unveiling basic structure-function relationships as well as investigating the molecular/structural basis of adaptation of living organisms to extreme conditions. However, a chronological analysis of decade-long studies conducted on Hbs is illuminating on the difficulties associated with the attempts of gaining functional insights from static structures. Here, we applied molecular dynamics (MD) simulations to explore the functional transition from the T to the R state of the hemoglobin of the Antarctic fish

Indexed as

HemoglobinsPerciformesAnimalsAntarctic RegionsHumansMolecular Dynamics SimulationOxygenHemoglobinsOxygen

Identifiers

PMID35930673

DOI10.1021/acs.jcim.2c00727

PMCPMC9400108

OpenAlexW4294916355

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.