Trial reportPloS one2022
Communicating about COVID-19 vaccine development and safety.
Trial report in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Communication-based interventions to increase COVID-19 vaccine willingness and uptake: a systematic review with meta-analysis.BMJ open · 2025Pooled it
- Comparing the Antimicrobial Resistance Crisis to the COVID-19 Pandemic: A Randomized Public Health Messaging Experiment.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Trial
- Effectiveness of a video-based intervention for COVID-19 vaccine acceptance among individuals with mental disorders: a randomized online experiment.Frontiers in public health · 2026Trial
- An effective COVID-19 vaccine hesitancy intervention focused on the relative risks of vaccination and infection.Scientific reports · 2024Trial
- What made people (more) positive toward the COVID-19 vaccine? Exploring positive and negative deviance perspectives.BMC public health · 2025Article
- The influence of audience's regulatory focus on the persuasive effect of different pro-vaccine messages.PloS one · 2025Article
- Predictors of COVID-19 vaccine uptake: an online three-wave survey study of US adults.BMC infectious diseases · 2024Article
- The COVID-19 inflammation and high mortality mechanism trigger.Immunogenetics · 2024Review
- Dynamic predictors of COVID-19 vaccination uptake and their interconnections over two years in Hong Kong.Nature communications · 2024Article
- A qualitative inquiry on drivers of COVID-19 vaccine hesitancy among adults in Kenya.PLOS global public health · 2024Article
- BNT162b2 COVID-19 Vaccines in Children, Adolescents and Young Adults with Cancer-A 1-Year Follow-Up.Vaccines · 2023Article
- Measuring the importance of influencing factor for COVID-19 vaccination intention in China.Frontiers in public health · 2023Article
- Drivers of the Intention to Receive a COVID-19 Booster Vaccine: Insights from the UK and Australia.Vaccines · 2022Article
- Using dialogues to increase positive attitudes towards COVID-19 vaccines in a vaccine-hesitant UK population.Royal Society open science · 2022Article
- Interventions to increase COVID-19 vaccine uptake: a scoping review.The Cochrane database of systematic reviews · 2022Article
- Self-reported health behaviors and risk perceptions following the COVID-19 vaccination rollout in the USA: an online survey study.Public health · 2022Article
- The Effectiveness of Interventions for Increasing COVID-19 Vaccine Uptake: A Systematic Review.Vaccines · 2022Review
- Veterans and Nonveterans Coping With Stress During 4 Months of COVID-19.Annals of family medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBeliefs that the risks from a COVID-19 vaccine outweigh the risks from getting COVID-19 and concerns that the vaccine development process was rushed and lacking rigor have been identified as important drivers of hesitancy and refusal to get a COVID-19 vaccine. We tested whether messages designed to address these beliefs and concerns might promote intentions to get a COVID-19 vaccine.
methodWe conducted an online survey fielded between March 8-23, 2021 with US Veteran (n = 688) and non-Veteran (n = 387) respondents. In a between-subjects experiment, respondents were randomly assigned to a control group (with no message) or to read one of two intervention messages: 1. a fact-box styled message comparing the risks of getting COVID-19 compared to the vaccine, and 2. a timeline styled message describing the development process of the COVID-19 mRNA vaccines.
resultsMost respondents (60%) wanted a COVID-19 vaccine. However, 17% expressed hesitancy and 23% did not want to get a COVID-19 vaccine. The fact-box styled message and the timeline message did not significantly improve vaccination intentions, F(2,358) = 0.86, p = .425, [Formula: see text] = .005, or reduce the time respondents wanted to wait before getting vaccinated, F(2,306) = 0.79, p = .453, [Formula: see text] = .005, compared to no messages. DISCUSSION: In this experimental study, we did not find that providing messages about vaccine risks and the development process had an impact on respondents' vaccine intentions. Further research is needed to identify how to effectively address concerns about the risks associated with COVID-19 vaccines and the development process and to understand additional factors that influence vaccine intentions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.