Evidence map›Paper›PMID 35930191›Full record

SynthesisSleep & breathing = Schlaf & Atmung2023

Efficacy of CPAP duration and adherence for cognitive improvement in patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials.

Jiaxin Li, Wenjie Yan, Minhan Yi, Ruihan Lin, Zini Huang, Yuan Zhang

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Sleep & breathing = Schlaf & Atmung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Sleep Abnormalities and Risk of Alzheimer's Disease.Current neurology and neuroscience reports · 2025
    Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jiaxin Li *Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wenjie Yan *Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Minhan Yi *Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ruihan LinDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zini HuangBangor College, Central South University of Forestry and Technology, Changsha, Hunan, China.
Yuan ZhangDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China. zhangyuan9194@csu.edu.cn.ORCID 0000-0003-0577-7129
Central South University · CNCentral South University of Forestry and Technology · CN

Funding

Degree & Postgraduate Education Reform Project of Central South University No. 2021YJSKSA10Hunan Provincial Natural Science Foundation of China No. 2021JJ80079National Natural Science Foundation of China No. 82001357Research Project of Laboratory Construction and Management of Central South University No. 202120Undergraduate Education Reform Project of Central South University No. 2021CG065Undergraduate Education Reform Project of Central South University No. 2021CG068Youth Science Foundation of Xiangya Hospital No. 2019Q17
6 · The paper itself

Abstract

purposeObstructive sleep apnea (OSA) can impair cognition. Continuous positive airway pressure (CPAP) is a recommended treatment for OSA but its effectiveness on cognitive improvement is uncertain, a finding which may be biased by various durations and adherence to treatment with CPAP. In a meta-analysis assessing high-quality randomized controlled trials (RCTs), we estimated whether or not CPAP benefits cognition in patients with OSA.

methodsPRISMA criteria were followed in the performance of this meta-analysis. The weighted mean difference (WMD) and 95% confidence interval (CI) of six neuropsychological scores covering eight cognitive domains were used to evaluate the benefit between CPAP and non-CPAP interventions. Subgroups of different therapeutic durations and adherence, which were divided into short-term (< 8 weeks) and long-term (≥ 12 weeks) durations, and poor (nighttime < 4 h/night) and good (nighttime ≥ 4 h/night) adherence were also analyzed.

resultsAmong 16 RCTs, 1529 participants with OSA were included. Comparing the CPAP group and the control group for all treatment durations and adherence, a mild improvement for digit span forward which reflected short-term memory was observed (WMD[95%CI] = 0.67[0.03,1.31], p = 0.04). Trail making test-part B, which reflected executive function was improved for participants with OSA who had good adherence to CPAP (WMD[95%CI] =  - 6.24[- 12.60,0.12], p = 0.05). Patients with OSA who received short-term CPAP treatment (WMD[95%CI] =  - 7.20[- 12.57, - 1.82], p = 0.009) had a significant improvement in executive function when compared with controls. There was no statistical difference for all scales between long-term (≥ 12 weeks) CPAP treatment group and control group.

conclusionThe effectiveness of CPAP on cognitive improvement in patients with OSA is limited, although good adherence to CPAP can mildly benefit executive function with short-term effectiveness.

Indexed as

Continuous Positive Airway PressureSleep Apnea, ObstructiveCognitionExecutive FunctionHumansRandomized Controlled Trials as TopicCognitive improvementCPAP treatmentObstructive sleep apneaSleepiness

Identifiers

PMID35930191
OpenAlexW4289884187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.