Evidence map›Paper›PMID 35930032›Full record

SynthesisJournal of neurology2022

Evidence for cognitive impairment in patients with vestibular disorders.

Divya A Chari, Amsal Madhani, Jeffrey D Sharon, Richard F Lewis

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07627087 (Vestibular Implant Tested in Patients With Peripheral Vestibular Damage), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07627087 narecruitingnot on this mapstarted 2026, after this paper: background citation

Vestibular Implant Tested in Patients With Peripheral Vestibular Damage: Effects on Spatial Orientation, Navigation, and Neuropsychologic Function

TypeinterventionalSponsorMassachusetts Eye and Ear InfirmaryRan2026 to 2029Enrolled20ConditionsVestibular Dysfunction, Bilateral Vestibular Loss, Vestibular ImplantArmsvestibular implant stimulation
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Divya A ChariDepartment of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA. Divya_Chari@meei.harvard.edu.ORCID http://orcid.org/0000-0002-7434-6923
Amsal MadhaniJenks Vestibular Physiology Lab, Massachusetts Eye and Ear, Boston, MA, USA.
Jeffrey D SharonDepartment of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, CA, USA.
Richard F LewisDepartment of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Massachusetts Eye and Ear Infirmary · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveExtensive animal research has shown that vestibular damage can be associated with cognitive deficits. More recently, new evidence has emerged linking vestibular disorders to cognitive impairment in humans. Herein, we review contemporary research on the pathophysiology of cognitive-vestibular interactions and discuss its emerging clinical relevance. DATA SOURCES: PubMed, Embase, and Cochrane databases. REVIEW

methodsA systematic literature search was performed with combinations of search terms: "cognition," "cognitive impairment," "chronic fatigue," "brain fog," "spatial navigation," "attention," "memory," "executive function," "processing speed," and "vestibular hypofunction." Relevant articles were considered for inclusion, including basic and clinical studies, case series, and major reviews.

conclusionsPatients with vestibular disorders can demonstrate long-term deficits in both spatial and nonspatial cognitive domains. The underlying mechanism(s) linking the vestibular system to cognitive function is not well characterized, but several neuro-biologic correlates have been identified. Additional screening tools are required to identify individuals at risk for cognitive impairment, and further research is needed to determine whether treatment of vestibular dysfunction has the capacity to improve cognitive function. IMPLICATIONS FOR PRACTICE: Physicians should be aware of emerging data supporting the presence of cognitive deficits in patients with vestibular disorders. Prevention and treatment of long-term cognitive deficits may be possible through screening and rehabilitation.

Indexed as

Biological ProductsCognitive DysfunctionSpatial NavigationVestibular DiseasesAnimalsCognitionHumansBiological ProductsBrain fogCognitionDizzinessImbalanceVestibular disordersVestibular hypofunction

Identifiers

PMID35930032
OpenAlexW4289886842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.