ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023
Clinical and Molecular Analyses of Recurrent Gram-Negative Bloodstream Infections.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Loss of O-antigen due toScience advances · 2026Article
- Predictors and outcomes of recurrent bloodstream infection in hematological malignancies: a multicenter real-world study.Frontiers in cellular and infection microbiology · 2026Observational
- A single-center retrospective study of pathogen distribution and antibiotic resistance of bloodstream infections in emergency department.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- Persistent Gram-negative Bloodstream Infection Increases the Risk of Recurrent Bloodstream Infection With the Same Species.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Prenatal and Postnatal Disparities in Very-Preterm Infants in a Study of Infections between 2018-2023 in Southeastern US.Tropical medicine and infectious disease · 2024Article
- Is Short-Course Antibiotic Therapy Suitable for Pseudomonas aeruginosa Bloodstream Infections in Onco-hematology Patients With Febrile Neutropenia? Results of a Multi-institutional Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- In-patient evolution of a high-persisterProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Prolonged bacterial carriage and hospital transmission detected by whole genome sequencing surveillance.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe causes and clinical characteristics of recurrent gram-negative bacterial bloodstream infections (GNB-BSI) are poorly understood.
methodsWe used a cohort of patients with GNB-BSI to identify clinical characteristics, microbiology, and risk factors associated with recurrent GNB-BSI. Bacterial genotyping (pulsed-field gel electrophoresis [PFGE] and whole-genome sequencing [WGS]) was used to determine whether episodes were due to relapse or reinfection. Multivariable logistic regression was used to identify risk factors for recurrence.
resultsOf the 1423 patients with GNB-BSI in this study, 60 (4%) had recurrent GNB-BSI. Non-White race (odds ratio [OR], 2.35; 95% confidence interval [CI], 1.38-4.01; P = .002), admission to a surgical service (OR, 2.18; 95% CI, 1.26-3.75; P = .005), and indwelling cardiac device (OR, 2.73; 95% CI, 1.21-5.58; P = .009) were associated with increased risk for recurrent GNB-BSI. Among the 48 patients with recurrent GNB-BSI whose paired bloodstream isolates underwent genotyping, 63% were due to relapse (30 of 48) and 38% were due to reinfection (18 of 48) based on WGS. Compared with WGS, PFGE correctly differentiated relapse and reinfection in 98% (47 of 48) of cases. Median time to relapse and reinfection was similar (113 days; interquartile range [IQR], 35-222 vs 174 days; IQR, 69-599; P = .13). Presence of a cardiac device was associated with relapse (relapse: 7 of 27, 26%; nonrelapse: 65 of 988, 7%; P = .002).
conclusionsIn this study, recurrent GNB-BSI was most commonly due to relapse. PFGE accurately differentiated relapse from reinfection when compared with WGS. Cardiac device was a risk factor for relapse.
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