Evidence map›Paper›PMID 35929648›Full record

ArticleOrthopaedic surgery2022

Analysis of the Effect of Antibiotic Bone Cement in the Treatment of Diabetic Foot Ulcer through Tibia Transverse Transport.

Xiaofang Ding, Yusong Yuan, Hao Lu, Yuanli Wang, Kunyu Ji, Haorun Lv, Hailin Xu, Junlin Zhou

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Article in Orthopaedic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  4. Tibial Osteodistraction Angiogenesis for Diabetic Foot Ischemia: A Systematic Review and Meta-Analysis.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaofang DingDepartment of Orthopaedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Yusong YuanOrthopaedic Trauma Department, China-Japan Friendship Hospital, Beijing, China.
Hao LuDepartment of Trauma and Orthopaedics, Peking University People's Hospital, Peking University, Beijing, China.
Yuanli WangDepartment of Orthopaedics, Beijing Longfu Hospital, Beijing, China.
Kunyu JiDepartment of Orthopaedics, Beijing Longfu Hospital, Beijing, China.
Haorun LvDepartment of Orthopaedics, Beijing Longfu Hospital, Beijing, China.
Hailin XuDepartment of Trauma and Orthopaedics, Peking University People's Hospital, Peking University, Beijing, China.ORCID https://orcid.org/0000-0003-1829-3852
Junlin ZhouDepartment of Orthopaedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0001-8646-8779

Funding

Capital's Funds for Health Improvement and Research 2020-2-4086Key Laboratory of Trauma and Neural Regeneration (Peking University), Ministry of EducationPilot project on clinical collaboration of major and difficult diseases of Chinese and Western medicine 201803190106the National Key Research and Development Program of China 2019YFB1311403
6 · The paper itself

Abstract

objectiveTo explore the efficacy of antibiotic bone cement (ABC) combined with the modified tibial transverse transport (mTTT) on the treatment of severe diabetic foot with infection.

methodsA retrospective cohort study was conducted of 243 patients with TEXAS grade 3/4 stage D diabetic foot ulcers from December 2016 to December 2019. A total of 115 patients treated with mTTT were classified as the mTTT group (78 male and 37 female, mean age: 70.4 ± 6 years) and 128 patients who were treated with ABC combined with mTTT were in the ABC + mTTT group (89 male and 39 female, mean age: 68.9 ± 8 years). Follow-up records during treatment and 6 months after surgery were collected, including the time required for white blood cells (WBC) and C-reactive protein (CRP) to return to normal range, wound healing time, pain visual analog scale (VAS), ankle-brachial index (ABI), foot skin temperature, transcutaneous oxygen pressure measurement (TcPO

resultsThere were 128 cases in the ABC + mTTT group (89 male and 39 female, mean age: 68.9 ± 8 years) treated with ABC and mTTT, and 115 cases in the TTT group (78 male and 37 female, mean age: 70.4 ± 6 years) treated with mTTT alone. The time required for WBC and CRP to return to the normal range and wound healing time in the ABC + mTTT group were significantly shorter than those in the mTTT group (12.9 ± 4.6 vs. 22.6 ± 1.6 days, t = 3.979, p < 0.001; 25.3 ± 1.3 vs. 31.3 ± 2.3 days, t = 4.261, p = 0.001; 11.9 ± 3.8 vs. 15.9 ± 3.9 days, t = 4.539, p < 0.001). There were no significant intergroup differences in the foot skin temperature, VAS score, ABI, and TcPO

conclusionAlthough the application of ABC with mTTT for treatment of diabetic foot ulcers did not affect the wound healing time and ankle blood supply in the mid-term, it could control ulcer infection faster and accelerate wound healing.

Indexed as

Diabetes MellitusDiabetic FootAgedAnti-Bacterial AgentsBone CementsC-Reactive ProteinFemaleHumansMaleMiddle AgedOxygenRetrospective StudiesTibiaTreatment OutcomeAnti-Bacterial AgentsBone CementsC-Reactive ProteinOxygenAntibiotic bone cementDiabetic foot ulcerInfectionTibial transverse translation

Identifiers

PMID35929648
PMCPMC9483062

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.