Evidence map›Paper›PMID 35929593›Full record

ArticleActa biochimica et biophysica Sinica2022

Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway.

Duo Ma, Linlin Hu, Jinyuan Wang, Min Luo, Aihong Liang, Xiaocan Lei, Biyun Liao, Meixiang Li, Ming Xie, Haicheng Li and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Duo MaHunan Province Collaborative Innovation Base of Endocrinology & Metabolism Science and Education for Postgraduates, The First Affiliated Hospital of Shaoyang University and Hengyang Medical School, University of South China, Hengyang 422000, China.
Linlin HuReproductive Medicine Center, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.
Jinyuan WangHunan Province Collaborative Innovation Base of Endocrinology & Metabolism Science and Education for Postgraduates, The First Affiliated Hospital of Shaoyang University and Hengyang Medical School, University of South China, Hengyang 422000, China.
Min LuoHunan Province Collaborative Innovation Base of Endocrinology & Metabolism Science and Education for Postgraduates, The First Affiliated Hospital of Shaoyang University and Hengyang Medical School, University of South China, Hengyang 422000, China.
Aihong LiangHunan Province Collaborative Innovation Base of Endocrinology & Metabolism Science and Education for Postgraduates, The First Affiliated Hospital of Shaoyang University and Hengyang Medical School, University of South China, Hengyang 422000, China.
Xiaocan LeiHunan Province Collaborative Innovation Base of Endocrinology & Metabolism Science and Education for Postgraduates, The First Affiliated Hospital of Shaoyang University and Hengyang Medical School, University of South China, Hengyang 422000, China.
Biyun LiaoReproductive Medicine Center, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.
Meixiang LiHunan Province Collaborative Innovation Base of Endocrinology & Metabolism Science and Education for Postgraduates, The First Affiliated Hospital of Shaoyang University and Hengyang Medical School, University of South China, Hengyang 422000, China.
Ming XieInstitute of Clinical Anatomy & Reproductive Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
Haicheng LiInstitute of Clinical Anatomy & Reproductive Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
Yiwei GongInstitute of Clinical Anatomy & Reproductive Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
Dan ZiInstitute of Clinical Anatomy & Reproductive Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
Xiangrun LiHunan Province Collaborative Innovation Base of Endocrinology & Metabolism Science and Education for Postgraduates, The First Affiliated Hospital of Shaoyang University and Hengyang Medical School, University of South China, Hengyang 422000, China.
Xi ChenHunan Province Collaborative Innovation Base of Endocrinology & Metabolism Science and Education for Postgraduates, The First Affiliated Hospital of Shaoyang University and Hengyang Medical School, University of South China, Hengyang 422000, China.
Xucai LiaoHunan Province Collaborative Innovation Base of Endocrinology & Metabolism Science and Education for Postgraduates, The First Affiliated Hospital of Shaoyang University and Hengyang Medical School, University of South China, Hengyang 422000, China.
Affiliated Hospital of Youjiang Medical University for Nationalities · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spermatogenic dysfunction is one of the major secondary complications of diabetes; however, the underlying mechanisms remain ill-defined, and there is no available drug or strategy for the radical treatment of diabetic spermatogenic dysfunction. Therefore, the objective of this study is to investigate the protective effects of nicotinamide mononucleotide (NMN) on testicular spermatogenic function in streptozotocin (STZ)-induced diabetic mice. The results show that oral administration of NMN significantly increases the body and testis weight and the number of sperms. Moreover, the abnormal sperm count and the rate of sperm malformation are significantly decreased compared with the saline-treated diabetic mice. Histological analysis reveals that NMN treatment significantly increases the area and diameter of seminiferous tubules, accompanied by an increased number of spermatogenic cells and sperms. Immunohistochemistry and qRT-PCR results show that NMN increases Bcl-2 expression and decreases Bax expression in the testis. NMN also increases the protein expression of Vimentin and the mRNA expressions of

Indexed as

Diabetes Mellitus, ExperimentalNicotinamide MononucleotideAnimalsGlycolysisMaleMiceSemenStreptozocinNicotinamide MononucleotideStreptozocindiabetesglycolysisnicotinamide mononucleotideSertoli cellspermatogenic function

Identifiers

PMID35929593
PMCPMC9828322
OpenAlexW4289838809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.