Evidence map›Paper›PMID 35929448›Full record

ArticleJournal of the American Heart Association2022

von Willebrand Factor: A Central Regulator of Arteriovenous Fistula Maturation Through Smooth Muscle Cell Proliferation and Outward Remodeling.

Suzanne L Laboyrie, Margreet R de Vries, Alwin de Jong, Hetty C de Boer, Reshma A Lalai, Laisel Martinez, Roberto I Vazquez-Padron, Joris I Rotmans

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Angiopoietin-2 binds to multiple interactive sites within von Willebrand factor.Research and practice in thrombosis and haemostasis · 2023
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Suzanne L LaboyrieInternal Medicine Leiden University Medical Centre Leiden The Netherlands.ORCID 0000-0002-8659-1838
Margreet R de VriesSurgery Leiden University Medical Centre Leiden The Netherlands.ORCID 0000-0002-3648-9130
Alwin de JongSurgery Leiden University Medical Centre Leiden The Netherlands.ORCID 0000-0002-4556-5393
Hetty C de BoerInternal Medicine Leiden University Medical Centre Leiden The Netherlands.ORCID 0000-0002-2677-4640
Reshma A LalaiInternal Medicine Leiden University Medical Centre Leiden The Netherlands.
Laisel MartinezVascular Surgery University of Miami Miami FL.ORCID 0000-0002-3009-8761
Roberto I Vazquez-PadronVascular Surgery University of Miami Miami FL.
Joris I RotmansInternal Medicine Leiden University Medical Centre Leiden The Netherlands.ORCID 0000-0001-9682-6234
Leiden University Medical Center · NLLeiden University · NLUniversity of Miami · US

Funding

Dual Role of Lysyl Oxidase in Arteriovenous Fistula FailureR01DK121227 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHIU, YAN-TING E., VAZQUEZ PADRON, ROBERTO IRENARDO · 2019 to 2023
$2.1M
Vascular Progenitor Cells in Arteriovenous Fistula StenosisR01DK098511 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ANDREOPOULOS, FOTIOS MATTHAIOS, SALMAN, LOAY HATEM · 2013 to 2016
$1.5M
Cellular Mechanisms of Mac-1 Mediated AtheroprotectionK08HL151747 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MARTINEZ, LAISEL · 2020 to 2024
$575k
The Multiple Roles of Lysyl Oxidase in Arteriovenous Fistula FailureI01BX004658 · VA · MIAMI VA HEALTH CARE SYSTEM · PI VAZQUEZ PADRON, ROBERTO IRENARDO · 2020 to 2023
–
BLRD VA I01 BX004658NHLBI NIH HHS K08 HL151747NIDDK NIH HHS R01 DK098511NIDDK NIH HHS R01 DK121227
6 · The paper itself

Abstract

Background Arteriovenous fistula (AVF) maturation failure is a main limitation of vascular access. Maturation is determined by the intricate balance between outward remodeling and intimal hyperplasia, whereby endothelial cell dysfunction, platelet aggregation, and vascular smooth muscle cell (VSMC) proliferation play a crucial role. von Willebrand Factor (vWF) is an endothelial cell-derived protein involved in platelet aggregation and VSMC proliferation. We investigated AVF vascular remodeling in vWF-deficient mice and vWF expression in failed and matured human AVFs. Methods and Results Jugular-carotid AVFs were created in wild-type and vWF

Indexed as

Arteriovenous FistulaArteriovenous Shunt, SurgicalMyocytes, Smooth Musclevon Willebrand FactorAnimalsCell ProliferationHumansHyperplasiaMiceMice, Knockoutvon Willebrand FactorAVF maturationintimal hyperplasiaoutward remodelingvon Willebrand FactorVSMC

Identifiers

PMID35929448
PMCPMC9496319
OpenAlexW4289942231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.