Evidence map›Paper›PMID 35929177›Full record

ArticleJournal of the American Geriatrics Society2022

Analysis of lumbar spine stenosis specimens for identification of amyloid.

Mathew S Maurer, Dia Smiley, Eli Simsolo, Fabrizio Remotti, Angela Bustamante, Sergio Teruya, Stephen Helmke, Andrew J Einstein, Ronald Lehman, Jon T Giles and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Gait abnormalities in older adults with transthyretin cardiac amyloidosis.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Cardiac amyloidosis: state-of-the-art review.Journal of geriatric cardiology : JGC · 2023
    Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Mathew S MaurerColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Dia SmileyColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Eli SimsoloColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Fabrizio RemottiColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Angela BustamanteColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Sergio TeruyaColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Stephen HelmkeColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Andrew J EinsteinColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Ronald LehmanColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Jon T GilesColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Jeffery W KellyColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Felix TsaiColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
William S BlanerColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Pierre-Jacques BrunColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Ron I RiesenburgerColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
James KryzanskiColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Cindy VargaColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Ayan R PatelColumbia University Irving Medical Center/New York Presbyterian Hospital, Scripps Clinic, Tufts Medical Center, New York, New York, USA.
Columbia University Irving Medical Center · USColumbia University · USTufts Medical Center · USNewYork–Presbyterian Hospital · USScripps Clinic · US

Funding

SCAN-MP (Screening for Cardiac Amyloidosis with Nuclear imaging in Minority Populations) COVID-19 SuppplementR01HL139671 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAURER, MATHEW S, RUBERG, FREDERICK LIEF · 2019 to 2023
$7.4M
Midcareer Mentoring Award for Patient Oriented Research in Geriatric CardiologyK24AG036778 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAURER, MATHEW S · 2010 to 2020
$1.6M
Analysis of Lumbar Spine Stenosis Speciments for Early Identification of TTR Cardiac AmyloidosisR21AG058348 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAURER, MATHEW S · 2018 to 2019
$456k
NHLBI NIH HHS R01 HL139671NIA NIH HHS K24 AG036778NIA NIH HHS R21 AG058348
6 · The paper itself

Abstract

backgroundLumbar spinal stenosis (LSS) is a common reason for spine surgery in which ligamentum flavum is resected. Transthyretin (TTR) amyloid is an often unrecognized and potentially modifiable mechanism for LSS that can also cause TTR cardiac amyloidosis. Accordingly, older adult patients undergoing lumbar spine (LS) surgery were evaluated for amyloid and if present, the precursor protein, as well as comprehensive characterization of the clinical phenotype.

methodsA prospective, cohort study in 2 academic medical centers enrolled 47 subjects (age 69 ± 7 years, 53% male) undergoing clinically indicated LS decompression. The presence of amyloid was evaluated by Congo Red staining and in those with amyloid, precursor protein was determined by laser capture microdissection coupled to mass spectrometry (LCM-MS). The phenotype was assessed by disease-specific questionnaires (Swiss Spinal Stenosis Questionnaire and Kansas City Cardiomyopathy Questionnaire) and the 36-question short-form health survey, as well as biochemical measures (TTR, retinol-binding protein, and TTR stability). Cardiac testing included technetium-99m-pyrophosphate scintigraphy, electrocardiograms, echocardiograms, and cardiac biomarkers as well as measures of functional capacity.

resultsAmyloid was detected in 16 samples (34% of participants) and was more common in those aged ≥ 75 years of age (66.7%) compared with those <75 years (22.3%, p < 0.05). LCM-MS demonstrated TTR as the precursor protein in 62.5% of participants with amyloid while 37.5% had an indeterminant type of amyloid. Demographic, clinical, quality-of-life measures, electrocardiographic, echocardiographic, and biochemical measures did not differ between those with and without amyloid. Among those with TTR amyloid (n = 10), one subject had cardiac involvement by scintigraphy.

conclusionsAmyloid is detected in more than a third of older adults undergoing LSS. Amyloid is more common with advancing age and is particularly common in those >75 years old. No demographic, clinical, biochemical, or cardiac parameter distinguished those with and without amyloid. In more than half of subjects with LS amyloid, the precursor protein was TTR indicating the importance of pathological assessment.

Indexed as

AmyloidosisCardiomyopathiesSpinal StenosisAgedAmyloidConstriction, PathologicFemaleHumansMaleMiddle AgedPrealbuminProspective StudiesAmyloidPrealbuminamyloidosiscardiaclumbar spinal stenosistransthyretin

Identifiers

PMID35929177
PMCPMC9771886
OpenAlexW4289861477

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.