ArticleThe British journal of surgery2022
Major surgical postoperative complications and survival in breast cancer: Swedish population-based register study in 57 152 women.
Article in The British journal of surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Postoperative complications after salvage mastectomy and repeat breast-conserving surgery in patients with IBTR after previous breast-conserving surgery: a multicenter, retrospective cohort study.Breast cancer research and treatment · 2026Observational
- The 19th St. Gallen international breast cancer conference 'primary therapy of patients with early breast cancer. Evidence, controversies, consensus': key moments and breakthroughs.Ecancermedicalscience · 2026Article
- Major systemic infection following breast cancer surgery and oncological outcomes.The British journal of surgery · 2025Article
- Complication Rates are Low After Invasive Procedures on the Lactating Breast in Patients Treated for Breast Cancer During Pregnancy.Annals of surgical oncology · 2025Article
- ASO Author Reflections: To Wean or Not to Wean: Surgical Interventions on the Lactating Breast.Annals of surgical oncology · 2025Article
- Real-world survival outcomes of neoadjuvant versus adjuvant chemotherapy in operable triple-negative breast cancer: a propensity score matched registry-based study.Acta oncologica (Stockholm, Sweden) · 2025Article
- Recurrence Patterns and Long-Term Results After Curative Surgery for Patients With Breast Cancer.Annals of surgical oncology · 2025Article
- Survival after standard or oncoplastic breast-conserving surgery versus mastectomy for breast cancer.BJS open · 2025Article
- PRESCO: an online tool for predicting severe pulmonary complications and survival after cancer surgery.Frontiers in oncology · 2025Article
- Article
- Mobile Applications in Breast Cancer Postoperative Care: A Scoping Review.Cancer medicine · 2024Article
- Postoperative complications after breast cancer surgery and effect on recurrence and survival: population-based cohort study.BJS open · 2024Article
- Which real indications remain for mastectomy?Lancet regional health. Americas · 2024Article
- Quality of life and satisfaction of patients after oncoplastic or traditional breast-conserving surgery using the BREAST-Q (BCT module): a prospective study.Breast cancer (Tokyo, Japan) · 2023Article
- Medical and surgical postoperative complications after breast conservation versus mastectomy in older women with breast cancer: Swedish population-based register study of 34 139 women.The British journal of surgery · 2023Article
- Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundPostoperative complications may activate prometastatic systemic pathways through tissue damage, wound healing, infection, and inflammation. Postoperative complications are associated with inferior survival in several types of cancer. The aim was to determine the association between postoperative complications and survival in breast cancer.
methodsThis population-based cohort included women operated for T1-3 N0-3 M0 invasive breast cancer in Sweden from 2008 to 2017. Only major surgical postoperative complications leading to readmission and/or reoperation within 30 days were considered. Main outcomes were overall survival (OS) and breast cancer-specific survival (BCSS). Prospectively collected nationwide register data were used. Multivariable Cox models were adjusted for clinical and socioeconomic confounders and co-morbidity.
resultsAmong 57 152 women, major surgical postoperative complications were registered for 1854 patients. Median follow-up was 6.22 (0.09-11.70) years. Overall, 9163 patients died, and 3472 died from breast cancer. Major surgical postoperative complications were more common after mastectomy with or without immediate reconstruction (7.3 and 4.3 per cent respectively) than after breast-conserving surgery (2.3 per cent). Unadjusted 5-year OS and BCSS rates were 82.6 (95 per cent c.i. 80.8 to 84.5) and 92.1 (90.8 to 93.5) per cent respectively for women with a major surgical postoperative complication, and 88.8 (88.6 to 89.1) and 95.0 (94.8 to 95.2) per cent for those without a complication (P < 0.001). After adjustment, all-cause and breast cancer mortality rates remained higher after a major surgical postoperative complication (OS: HR 1.32, 95 per cent c.i. 1.15 to 1.51; BCSS: HR 1.31, 1.04 to 1.65). After stratification for type of breast surgery, this association remained significant only for women who had mastectomy without reconstruction (OS: HR 1.41, 1.20 to 1.66; BCSS: HR 1.36, 1.03 to 1.79).
conclusionMajor surgical postoperative complications are associated with inferior survival, especially after mastectomy. These results underline the importance of surgical de-escalation.
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