SynthesisComputational and mathematical methods in medicine2022
Effects of Periodontal Treatment on Levels of Proinflammatory Cytokines in Patients with Chronic Periodontitis: A Meta-Analysis.
Synthesis in Computational and mathematical methods in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 8 citations in OpenAlex.
- Annexin levels in GCF determine the imbalance of periodontal inflammatory regulation.Scientific reports · 2024Article
- Retracted: Effects of Periodontal Treatment on Levels of Proinflammatory Cytokines in Patients with Chronic Periodontitis: A Meta-Analysis.Computational and mathematical methods in medicine · 2023Article
Corrections and comments
- Retraction · 2023-07-19Concerns/Issues about Data · Concerns/Issues about Referencing/Attributions · Concerns/Issues about Peer Review · Investigation by Journal/Publisher · Investigation by Third Party · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: During the progression of chronic periodontitis (CP), changes in the levels of inflammatory factors are detected in serum and gingival sulcus fluid (GCF). The aim of this meta-analysis was to systematically evaluate the effect of periodontal treatment on GCF and serum proinflammatory cytokines (IL-6, TNF- Methods: Literature searches were performed through PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang Database. Randomized controlled trials comparing cytokine levels in periodontal treatment (experimental group) and control group between 2015 and 2020 were included. Results: There were a total of 13 studies included with 1220 patients. There were 630 cases in the experimental group and 590 cases in the control group. The meta-analysis showed that IL-6 levels in the GCF (SMD = -2.88, 95% CI (-3.68, -2.09), Conclusion: After periodontal therapy, the proinflammatory cytokines in the GCF and serum of patients with CP were significantly decreased compared with those before treatment, and the efficacy was remarkable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.