Evidence map›Paper›PMID 35928867›Full record

ReviewFrontiers in oncology2022

Tuberous Sclerosis Complex With Multiple Organ Tumors: Case Report and Literature Review.

Xinhe Zhang, Xinping Zhong, Xuyong Lin, Xuedan Li, Haoyu Tian, Bing Chang, Ying Wang, Jing Tong, Ningning Wang, Dan Li and 6 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Splenic hamartoma mimicking angiosarcoma: A case report.World journal of clinical cases · 2025
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Xinhe ZhangGastroenterology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
Xinping ZhongDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
Xuyong LinDepartment of Pathology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Xuedan LiRadiology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
Haoyu TianThe 3rd Clinical Department, China Medical University, Shenyang, China.
Bing ChangGastroenterology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
Ying WangGastroenterology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
Jing TongGastroenterology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
Ningning WangGastroenterology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
Dan LiGastroenterology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
Xiuli JinGastroenterology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
Die HuangGastroenterology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
Yanmeng WangGastroenterology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
Huipeng CuiGastroenterology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
Lin GuanGastroenterology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
Yiling LiGastroenterology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
First Hospital of China Medical University · CNChina Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic neuroendocrine neoplasms (PNEN) are tumors that originate from neuroendocrine cells. Only about 1% patients are related to mutation of tuberous sclerosis complex gene. Here, we reported a rare case with involvement of multiple organs and space-occupying lesions. Initially, the patient was thought to have metastasis of a pancreatic tumor. However, the patient was diagnosed as pancreatic neuroendocrine tumors, liver perivascular epithelioid tumors, splenic hamartoma, and renal angiomyolipoma by pathological examination after surgery. We performed genetic mutation detection to identify that tuberous sclerosis complex 2 gene presented with a heterozygous variant. Tuberous sclerosis often presents with widespread tumors, but it is less common to present with pancreatic neuroendocrine tumors and liver perivascular tumors as highlighted in the case. So we analyzed the relationship between TSC gene mutations and related tumors. And we also reviewed the current molecular mechanisms and treatments for tuberous sclerosis complex.

Indexed as

liver perivascular epithelioid tumorspancreatic neuroendocrine neoplasmsrenal angiomyolipomasplenic hamartomatuberous sclerosis complex

Identifiers

PMID35928867
PMCPMC9343591
OpenAlexW4285797369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.