Evidence map›Paper›PMID 35928825›Full record

ArticleFrontiers in immunology2022

Innate immune activation as cofactor in pemphigus disease manifestation.

Ramona A Eichkorn, Morna F Schmidt, Elias Walter, Michael Hertl, Jens Malte Baron, Jens Waschke, Amir S Yazdi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ramona A EichkornDepartment of Dermatology, Eberhard Karl University of Tuebingen, Tuebingen, Germany.
Morna F SchmidtDepartment of Dermatology, Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) Aachen University, Aachen, Germany.
Elias WalterDepartment I, Institute of Anatomy and Cell Biology, Ludwig Maximilian University of Munich (LMU), Munich, Germany.
Michael HertlDepartment of Dermatology and Allergology, Philipps University of Marburg, Marburg, Germany.
Jens Malte BaronDepartment of Dermatology, Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) Aachen University, Aachen, Germany.
Jens WaschkeDepartment I, Institute of Anatomy and Cell Biology, Ludwig Maximilian University of Munich (LMU), Munich, Germany.
Amir S YazdiDepartment of Dermatology, Eberhard Karl University of Tuebingen, Tuebingen, Germany.
Ludwig-Maximilians-Universität München · DERWTH Aachen University · DEUniversity of Tübingen · DEPhilipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular mechanisms underlying auto-antibody-induced acantholysis in pemphigus vulgaris are subject of current research to date. To decipher the discrepancy between ubiquitous antibody binding to the epidermal desmosomes, but discontinuous disease manifestation, we were able to identify Ultraviolet A (UVA) as a cofactor for acantholysis. UVA induces interleukin (IL)-1 secretion in keratinocytes, mirroring innate immune system activation. In an

Indexed as

PemphigusAcantholysisCaspasesHumansImmunity, InnateImmunoglobulin GCaspasesImmunoglobulin Gcaspasesdesmogleininflammasomesinterleukin 1pemphigus vulgaris

Identifiers

PMID35928825
PMCPMC9343989
OpenAlexW4285794886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.