Evidence map›Paper›PMID 35928809›Full record

ArticleFrontiers in immunology2022

STAT3 gain-of-function is not responsible for low total IgE levels in patients with autoimmune chronic spontaneous urticaria.

Merle Sauer, Jörg Scheffel, Stefan Frischbutter, Niklas Mahnke, Marcus Maurer, Thomas Burmeister, Karoline Krause, Martin Metz

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. A case report of ADMIO type 1 caused by aFrontiers in immunology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Merle SauerInstitute of Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Jörg ScheffelInstitute of Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Stefan FrischbutterInstitute of Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Niklas MahnkeInstitute of Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Marcus MaurerInstitute of Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Thomas BurmeisterDepartment of Hematology, Oncology and Tumor Immunology, Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Karoline KrauseInstitute of Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Martin MetzInstitute of Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEFraunhofer Institute for Translational Medicine and Pharmacology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The pathogenesis of chronic spontaneous urticaria (CSU) has not been clarified entirely. Type IIb autoimmune chronic spontaneous urticaria (CSU Objective: Our aim was to investigate a possible underlying gain-of-function mutation or activating polymorphism in Methods: We included 10 patients with CSU Results: No differences were found in the prevalence of the tested SNPs between our patients and a control population. Moreover, we could not find any mutations or variants on the tested exons of Conclusion: In total, we could not find any evidence for our hypothesis that low IgE in patients with CSU

Indexed as

Chronic UrticariaImmunoglobulin ESTAT3 Transcription FactorGain of Function MutationHumansLeukocytes, MononuclearImmunoglobulin ESTAT3 protein, humanSTAT3 Transcription Factorautoimmune diseaseautoreactivitybasophil activation testchronic spontaneous urticariagain-of-function mutationimmunoglobulin Emast cellsignal transducer and activator of transcription 3

Identifiers

PMID35928809
PMCPMC9345496
OpenAlexW4285794230

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.