ArticleFrontiers in psychiatry2022
Early Effects of Repetitive Transcranial Magnetic Stimulation Combined With Sertraline in Adolescents With First-Episode Major Depressive Disorder.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Effects of repetitive transcranial magnetic stimulation in children and young people with psychiatric disorders: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- Efficacy and safety of non-invasive brain stimulation in combination with antidepressants in adolescents with depression: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Adjunctive repetitive transcranial magnetic stimulation for adolescents with first-episode major depressive disorder: a meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Low-frequency repetitive transcranial magnetic stimulation for children and adolescents with first-episode and drug-naïve major depressive disorder: A systematic review.Frontiers in psychiatry · 2023Pooled it
- Cost-utility analysis of repetitive transcranial magnetic stimulation and transcranial direct current stimulation as adjunctive therapies in Chinese patients with major depressive disorder.BMC psychiatry · 2026Article
- Altered dynamic functional connectivity characteristics in adolescent depression with childhood trauma: a pilot resting-state EEG study.Frontiers in psychology · 2026Article
- Exploratory analysis of symptom-specific efficacy of transcranial magnetic stimulation in adolescent depression.World journal of psychiatry · 2025Article
- Exploring Applications of Transcranial Magnetic Stimulation in Child and Adolescent Psychiatry: A Narrative Review.Journal of clinical medicine · 2025Review
- Integrating Dialectical Behaviour Therapy Into the Treatment of Adolescent Depression: A Retrospective Study.Actas espanolas de psiquiatria · 2025Article
- Antidepressant class and concurrent rTMS outcomes in major depressive disorder: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Effects of Transcranial Magnetic Stimulation Combined with Sertraline on Cognitive Level, Inflammatory Response and Neurological Function in Depressive Disorder Patients with Non-suicidal Self-injury Behavior.Actas espanolas de psiquiatria · 2024Article
- Attention-Dominated Cognitive Dysfunction May Be a Biological Marker for Distinguishing SA from SI in Adolescents: A Network Analysis Study Based on Adolescent Depression.Psychology research and behavior management · 2024Article
- Article
- Associations between sex differences, eating disorder behaviors, physical and mental health, and self-harm among Chinese adolescents.Journal of eating disorders · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Adolescence is a period of high incidence for depression. However, there is a limited treatment option for the adolescent depression. For treatment-resistant major depressive disorder, HF-rTMS of the left dorsolateral prefrontal cortex (DLPFC) appears therapeutically effective. The aim of the study is to explore the early effects of repetitive transcranial magnetic stimulation in combination with sertraline in adolescents with first-episode major depressive disorder. Methods: A total of 100 teenage patients with first-episode depression were randomly divided into the study groups. Both groups were treated with sertraline. In addition, the study group was treated with ten sessions of add-on rTMS. The control group was given sertraline only. The depressive symptom and cognitive function were assessed by the Hamilton depression rating scale 17 version (HAMD-17), Children's Depression Rating Scale-Revised (CDRS-R), Integrated visual and auditory continuous performance test (IVA-CPT), and THINC-it. Results: The number of early improvers after 2 weeks of treatment in the study group was statistically significant higher compared to the control group (95.83% vs 73.47%, χ Discussion: This is the most extensive blinded, randomized clinical study to date examining the efficacy of 10-Hz add-on rTMS for first-onset adolescent depression. Our results support that add-on rTMS accelerates the efficacy of the antidepressants, improving the depressive symptoms and cold cognitive function in first-episode adolescent depression. Clinical Trial Registration: [www.ClinicalTrials.gov], identifier [ChiCTR2100048534].
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