Evidence map›Paper›PMID 35928745›Full record

ArticleAnnals of translational medicine2022

High sodium reduced the expression of PTH1R and Klotho by inhibiting 1,25(OH)

Jie Gu, Jialin Shi, Xujiao Chen, Jianping Mao, Huaizhou You, Jing Chen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jie Gu *Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
Jialin Shi *Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
Xujiao ChenDivision of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
Jianping MaoDivision of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
Huaizhou YouDivision of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
Jing ChenDivision of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
Fudan University · CNHuashan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The proximal tubule is the sensing site of sodium and phosphate and the main place for the synthesis and metabolism of 1,25(OH) Methods: Human proximal tubule epithelial (HK-2) cells were treated with different concentrations of sodium/phosphate. The expression of 1α-OHase and 24-OHase was determined. Liquid chromatography/mass spectrometry (LC/MS) and enzyme-linked immunosorbent assay (ELISA) were used to detect the levels of 1,25(OH) Results: We found that high sodium decreased the expression of 1,25(OH) Conclusions: High sodium can decrease the synthesis of active vitamin D in the proximal tubules, affect the gene regulation of 1,25(OH)

Indexed as

1,25-dihydroxyvitamin D3High sodiumKlothoparathyroid receptor 1 (PTH1R)proximal tubule epithelial cells

Identifiers

PMID35928745
PMCPMC9347055
OpenAlexW4285548313

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.