ArticleJGH open : an open access journal of gastroenterology and hepatology2022
Molecular and clinicopathological analysis of three cases of gastric juvenile polyposis.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aim: Juvenile polyposis (JP) is a rare disease known to be associated with mutations either in Methods: We selected polyps from each patient displaying varying degrees of atypia and their nearby normal polyps and compared them using immunohistochemistry, Sanger sequencing, and loss of heterozygosity (LOH) analysis of Results: Two of the three cases were suspected of having germline Conclusions: These data suggest that strong nuclear expression of SMAD4, even when seemingly paradoxical, seems to be closely associated with dysplastic polyps in JP. Complete inactivation of
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