Evidence map›Paper›PMID 35928633›Full record

ArticleJournal of immunology research2022

The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways.

Seth A Domfeh, Patrick W Narkwa, Osbourne Quaye, Kwadwo A Kusi, Bright S Addy, Sian Lant, Rebecca P Sumner, Carlos Maluquer de Motes, Gordon A Awandare, Charles Ansah and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Seth A DomfehWest African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Ghana.ORCID https://orcid.org/0000-0002-1689-7663
Patrick W NarkwaDepartment of Clinical Microbiology, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID https://orcid.org/0000-0003-2490-7902
Osbourne QuayeWest African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Ghana.ORCID https://orcid.org/0000-0002-0621-876X
Kwadwo A KusiWest African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Ghana.ORCID https://orcid.org/0000-0001-5483-9985
Bright S AddyDepartment of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID https://orcid.org/0000-0002-2392-1158
Sian LantDepartment of Microbial Sciences, University of Surrey, Guildford, UK.
Rebecca P SumnerDepartment of Microbial Sciences, University of Surrey, Guildford, UK.ORCID https://orcid.org/0000-0003-0735-8649
Carlos Maluquer de MotesDepartment of Microbial Sciences, University of Surrey, Guildford, UK.ORCID https://orcid.org/0000-0003-4712-4601
Gordon A AwandareWest African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Ghana.ORCID https://orcid.org/0000-0002-8793-3641
Charles AnsahDepartment of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID https://orcid.org/0000-0001-6044-6117
Mohamed MutocheluhDepartment of Clinical Microbiology, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID https://orcid.org/0000-0002-1396-5085
Kwame Nkrumah University of Science and Technology · GHUniversity of Ghana · GHUniversity of Surrey · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Type 1 interferons (IFN-1) are pleiotropic cytokines with well-established anticancer and antiviral properties, particularly in mucosal tissues. Hence, natural IFN-1-inducing treatments are highly sought after in the clinic. Here, we report for the first time that cryptolepine, a pharmacoactive alkaloid in the medicinal plant

Indexed as

AlkaloidsAntineoplastic AgentsInterferon Type IQuinolinesHumansIndole AlkaloidsAlkaloidsAntineoplastic AgentscryptolepineIndole AlkaloidsInterferon Type IQuinolines

Identifiers

PMID35928633
PMCPMC9345703
OpenAlexW4288035941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.