Evidence map›Paper›PMID 35928317›Full record

ArticleSurgical neurology international2022

Ceftriaxone-induced encephalopathy in a patient with multicentric glioma.

Mariette Anto, Rajesh Shankar Iyer, Adarsh Manuel, Akarsh Jayachandran, Rosmy Jose, Nisha John, Puja Shyam, Anjitha Thankachan, Santhosh George Thomas, Biji Bahuleyan

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Surgical neurology international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mariette AntoDepartment of Neurosurgery, Lisie Hospital, Kochi, Kerala, India.
Rajesh Shankar IyerDepartment of Neurology, Kovai Medical Centre and Hospital, Coimbatore, Tamil Nadu, India.
Adarsh ManuelDepartment of Neurosurgery, Lisie Hospital, Kochi, Kerala, India.
Akarsh JayachandranDepartment of Neurosurgery, Lisie Hospital, Kochi, Kerala, India.
Rosmy JoseDepartment of Anaesthesia, Lisie Hospital, Kochi, Kerala, India.
Nisha JohnDepartment of Anaesthesia, Lisie Hospital, Kochi, Kerala, India.
Puja ShyamDepartment of Anaesthesia, Lisie Hospital, Kochi, Kerala, India.
Anjitha ThankachanDepartment of Neurosurgery, Lisie Hospital, Kochi, Kerala, India.
Santhosh George ThomasDepartment of Neurosurgery, Lisie Hospital, Kochi, Kerala, India.
Biji BahuleyanDepartment of Neurosurgery, Lisie Hospital, Kochi, Kerala, India.
Kovai Medical Center and Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ceftriaxone is a commonly used antibiotic in a wide range of local and systemic infections. Encephalopathy is a rare complication of ceftriaxone, often seen in older adults and those with renal insufficiency. Case Description: A 73-year-old lady with prior history of hypertension and dyslipidemia presented with the complaints of slurred speech, gait imbalance, nocturnal vomiting, and progressively worsening headache. A magnetic resonance imaging of the brain revealed two intracerebral lesions involving the right frontal and temporal lobes, suggestive of multicentric glioma. She underwent craniotomy and excision of these lesions. The biopsy was reported as intra-axial tumors with features suggestive of the WHO Grade IV glioma. Postoperatively, she did not wake up. An electroencephalogram demonstrated triphasic waves suggestive of encephalopathy. The probable diagnosis of ceftriaxone-induced encephalopathy was made after ruling out other causes of delayed awakening after surgery. Ceftriaxone was discontinued and the patient improved within 2 days of withdrawal of ceftriaxone. Conclusion: Drug-induced encephalopathy should be considered in the differential diagnosis of patients with delayed awakening after surgery. Discontinuation of the drug leads to the recovery of these patients.

Indexed as

CeftriaxoneEncephalopathyGliomaSurgery

Identifiers

PMID35928317
PMCPMC9345111
OpenAlexW4285591369

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.