Evidence map›Paper›PMID 35928131›Full record

ArticleFrontiers in neurology2022

Prospective CERAD Neuropsychological Assessment in Patients With Multiple System Atrophy.

Fabian Maass, Peter Hermann, Daniela Varges, Sabine Nuhn, Christoph van Riesen, Ala Jamous, Niels K Focke, Manuel Hewitt, Andreas Leha, Mathias Bähr and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Cognitive impairment in Parkinson's disease and other parkinsonian syndromes.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  2. Mild cognitive impairment in multiple system atrophy: a brain network disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Fabian MaassDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Peter HermannDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Daniela VargesDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Sabine NuhnDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Christoph van RiesenDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Ala JamousDepartment of Neuroradiology, University Medical Center Göttingen, Göttingen, Germany.
Niels K FockeDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Manuel HewittDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Andreas LehaDepartment of Medical Statistics, University Medical Center, Göttingen, Germany.
Mathias BährDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Inga ZerrDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Universitätsmedizin Göttingen · DEGerman Center for Neurodegenerative Diseases · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of the study was to characterize the pattern of cognitive dysfunction in patients with multiple system atrophy (MSA) applying a standardized neuropsychological assessment. A total of 20 patients with the diagnosis of probable or possible MSA were enrolled for neuropsychological assessment applying the CERAD plus battery. All patients were tested at baseline and 14/20 patients received additional follow-up assessments (median follow-up of 24 months). Additionally, relationship between cortical thickness values/subcortical gray matter volumes and CERAD subitems was evaluated at baseline in a subgroup of 13/20 patients. Trail Making Test (TMT) was the most sensitive CERAD item at baseline with abnormal performance (z-score < -1.28) in one or both pathological TMT items (TMT-A, TMT-B) in 60% of patients with MSA. Additionally, there was a significant inverse correlation between the volume of the left and the right accumbens area and the TMT A item after adjusting for age (left side:

Indexed as

CERAD neuropsychological assessment batteryexecutive dysfunctionmultiple system atrophy (MSA)neuropsychologytrail making test (TMT)

Identifiers

PMID35928131
PMCPMC9344909
OpenAlexW4286218354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.