Evidence map›Paper›PMID 35928129›Full record

ArticleFrontiers in neurology2022

Proteomic Profiling of Plasma Biomarkers Associated With Return to Sport Following Concussion: Findings From the NCAA and Department of Defense CARE Consortium.

Rany Vorn, Sara Mithani, Christina Devoto, Timothy B Meier, Chen Lai, Sijung Yun, Steven P Broglio, Thomas W McAllister, Christopher C Giza, Hyung-Suk Kim and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 15 institutions in 1 country.

Rany VornSchool of Nursing, Johns Hopkins University, Baltimore, MD, United States.
Sara MithaniNational Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Christina DevotoNational Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Timothy B MeierDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Chen LaiNational Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Sijung YunPredictiv Care, Mountain View, CA, United States.
Steven P BroglioMichigan Concussion Center, University of Michigan, Ann Arbor, MI, United States.
Thomas W McAllisterDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States.
Christopher C GizaDepartments of Pediatrics and Neurosurgery, University of California, Los Angeles, Los Angeles, CA, United States.
Hyung-Suk KimNational Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Daniel HuberDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Jaroslaw HarezlakDepartment of Epidemiology and Biostatistics School of Public Health-Bloomington, Indiana University, Bloomington, IN, United States.
Kenneth L CameronJohn A. Feagin Sports Medicine Fellowship, Keller Army Hospital, West Point, NY, United States.
Gerald McGintyUnited States Air Force Academy, Colorado Springs, CO, United States.
Jonathan JacksonUnited States Air Force Academy, Colorado Springs, CO, United States.
Kevin M GuskiewiczMatthew Gfeller Center, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Jason P MihalikMatthew Gfeller Center, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Alison BrooksDepartment of Orthopedics, Division of Sports Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.
Stefan DumaDepartment of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, United States.
Steven RowsonDepartment of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, United States.
Lindsay D NelsonDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Paul PasquinaCenter for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Michael A McCreaDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Jessica M GillSchool of Nursing, Johns Hopkins University, Baltimore, MD, United States.
Medical College of Wisconsin · USNational Institutes of Health · USUniformed Services University of the Health Sciences · USUnited States Air Force Academy · USUniversity of North Carolina at Chapel Hill · USVirginia Tech · USHenry M. Jackson Foundation · USIndiana University Bloomington · USIndiana University School of MedicineKeller Army Community Hospital · USNational Institute of Nursing Research · USThe University of Texas Health Science Center at San Antonio · USUniversity of California, Los Angeles · USUniversity of Michigan–Ann Arbor · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the plasma proteomic profiling in identifying biomarkers related to return to sport (RTS) following a sport-related concussion (SRC). Methods: This multicenter, prospective, case-control study was part of a larger cohort study conducted by the NCAA-DoD Concussion Assessment, Research, and Education (CARE) Consortium, athletes ( Results: We identified 87 plasma proteins significantly dysregulated (32 upregulated and 55 downregulated) in concussed athletes with recovery ≥14-days relative to recovery <14-days groups. The significantly dysregulated proteins were uploaded to Ingenuity Pathway Analysis (IPA) software for analysis. Pathway analysis showed that significantly dysregulated proteins were associated with STAT3 pathway, regulation of the epithelial mesenchymal transition by growth factors pathway, and acute phase response signaling. Conclusion: Our data showed the feasibility of large-scale plasma proteomic profiling in concussed athletes with a <14-days and ≥ 14-days recovery. These findings provide a possible understanding of the pathophysiological mechanism in neurobiological recovery. Further study is required to determine whether these proteins can aid clinicians in RTS decisions.

Indexed as

biomarkerconcussionproteomicreturn to sport (RTS)sport injuries

Identifiers

PMID35928129
PMCPMC9343581
OpenAlexW4285794697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.