Evidence map›Paper›PMID 35928010›Full record

ReviewFrontiers in neuroscience2022

Chemosensory Contributions of E-Cigarette Additives on Nicotine Use.

Natalie L Johnson, Theresa Patten, Minghong Ma, Mariella De Biasi, Daniel W Wesson

Abstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. The role of TRPA1 in lung cancer.Translational lung cancer research · 2025
    Review
  5. Chemosensory tobacco product toxicology part 2: toxicological testing, assays, and state of the science.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  6. Chemosensory tobacco product toxicology part 1: sensory mechanisms.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. The COVID-19 and Taste Lab: A Mini Course-Based Undergraduate Research Experience on Taste Differences and COVID-19 Susceptibility.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Natalie L JohnsonDepartment of Pharmacology and Therapeutics, Center for Smell and Taste, Center for Addiction Research and Education, University of Florida, Gainesville, FL, United States.
Theresa PattenDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Minghong MaDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Mariella De BiasiDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Daniel W WessonDepartment of Pharmacology and Therapeutics, Center for Smell and Taste, Center for Addiction Research and Education, University of Florida, Gainesville, FL, United States.

Funding

Striatal mechanisms for e-cigarette reinforcement by flavorantsR01DA049545 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI DE BIASI, MARIELLA, MA, MINGHONG · 2019 to 2023
$3.2M
Flavored e-cigarette use in adolescents: Behavioral, cellular, and epigenetic mechanismsR01DA044205 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI DE BIASI, MARIELLA · 2018 to 2022
$2.2M
Circuitry and function of ventral striatum subregionsR01DA049449 · NIDA · UNIVERSITY OF FLORIDA · PI MA, MINGHONG, WESSON, DANIEL W · 2020 to 2024
$2.1M
Training Program in Chemosensory ScienceT32DC015994 · NIDCD · UNIVERSITY OF FLORIDA · PI Daniel W Wesson · 2018 to 2026
$1.4M
Olfactory Mechanisms Supporting Attraction to e-Cigarette OdorsF31DC020364 · NIDCD · UNIVERSITY OF FLORIDA · PI JOHNSON, NATALIE LEWIS · 2022 to 2023
$90k
NIDA NIH HHS R01 DA044205NIDA NIH HHS R01 DA049449NIDA NIH HHS R01 DA049545NIDCD NIH HHS F31 DC020364NIDCD NIH HHS T32 DC015994
6 · The paper itself

Abstract

While rates of smoking combustible cigarettes in the United States have trended down in recent years, use of electronic cigarettes (e-cigarettes) has dramatically increased, especially among adolescents. The vast majority of e-cigarette users consume "flavored" products that contain a variety of chemosensory-rich additives, and recent literature suggests that these additives have led to the current "teen vaping epidemic." This review, covering research from both human and rodent models, provides a comprehensive overview of the sensory implications of e-cigarette additives and what is currently known about their impact on nicotine use. In doing so, we specifically address the oronasal sensory contributions of e-cigarette additives. Finally, we summarize the existing gaps in the field and highlight future directions needed to better understand the powerful influence of these additives on nicotine use.

Indexed as

addictionflavorsgustatorymenthololfactorytrigeminalTRPA1TRPM8

Identifiers

PMID35928010
PMCPMC9344001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.