Evidence map›Paper›PMID 35927930›Full record

SynthesisTropical medicine & international health : TM & IH2022

Strategies to detect and manage latent tuberculosis infection among household contacts of pulmonary TB patients in high TB burden countries - a systematic review and meta-analysis.

Karuna Devi Sagili, Malaisamy Muniyandi, Kalpita Shringarpure, Kavita Singh, Richard Kirubakaran, Raghuram Rao, Jamhoih Tonsing, Kuldeep Singh Sachdeva, Prathap Tharyan

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Tropical medicine & international health : TM & IH, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Karuna Devi SagiliInternational Union Against Tuberculosis and Lung Disease, South East Asia Office, New Delhi, India.
Malaisamy MuniyandiIndian Council of Medical Research (ICMR), National Institution for Research in Tuberculosis, Chennai, India.
Kalpita ShringarpureDepartment of Community Medicine, Medical College Baroda, Baroda, India.
Kavita SinghInternational Union Against Tuberculosis and Lung Disease, South East Asia Office, New Delhi, India.
Richard KirubakaranClinical Epidemiology Unit, Christian Medical Centre, Vellore, India.
Raghuram RaoNational TB Elimination Program, Central TB Division, Ministry of Health, New Delhi, India.
Jamhoih TonsingTechnical Advice and Partnerships Department, The Global Fund, Geneva, Switzerland.
Kuldeep Singh SachdevaInternational Union Against Tuberculosis and Lung Disease, South East Asia Office, New Delhi, India.
Prathap TharyanClinical Epidemiology Unit, Christian Medical Centre, Vellore, India.
International Union Against Tuberculosis and Lung Disease · USChristian Medical College & Hospital · INGlobal Fund to Fight AIDS, Tuberculosis and Malaria · CHIndian Council of Medical Research · INNew Delhi Tuberculosis Center · INSir Sayajirao General Hospital Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo summarise latent tuberculosis infection (LTBI) management strategies among household contacts of bacteriologically confirmed pulmonary tuberculosis (TB) patients in high-TB burden countries.

methodsPubMed/MEDLINE (NCBI) and Scopus were searched (January 2006 to December 2021) for studies reporting primary data on LTBI management. Study selection, data management and data synthesis were protocol-driven (PROSPERO-CRD42021208715). Primary outcomes were the proportions of LTBI, initiating and completing tuberculosis preventive treatment (TPT). Reported factors influencing the LTBI care cascade were qualitatively synthesised.

resultsFrom 3694 unique records retrieved, 58 studies from 23 countries were included. Most identified contacts were screened (median 99%, interquartile range [IQR] 82%-100%; 46 studies). Random-effects meta-analysis yielded pooled proportions for: LTBI 41% (95% confidence interval [CI] 33%-49%; 21,566 tested contacts); TPT initiation 91% (95% CI 79%-97%; 129,573 eligible contacts, 34 studies); TPT completion 65% (95% CI 54%-74%; 108,679 TPT-initiated contacts, 28 studies). Heterogeneity was significant (I

conclusionThe proportions of household contacts screened, detected with LTBI and initiated on TPT, though variable was high, but the proportions completing TPT were lower indicating current strategies used for LTBI management in high TB burden countries are not sufficient.

Indexed as

Latent TuberculosisTuberculosis, PulmonaryHumansdiagnosishigh TB burden settingshousehold contactsisoniazid preventive therapylatent TB infectionscreeningTB preventive therapytreatmenttuberculosis

Identifiers

PMID35927930
PMCPMC9825928
OpenAlexW4289889732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.