Evidence map›Paper›PMID 35927827›Full record

ArticleJournal of extracellular vesicles2022

Neoantigen-based cancer vaccination using chimeric RNA-loaded dendritic cell-derived extracellular vesicles.

Xiao Xiong, Xiurong Ke, Lu Wang, Yusheng Lin, Shuhong Wang, Zhimeng Yao, Kai Li, Yichen Luo, Fan Liu, Yunlong Pan and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of extracellular vesicles, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 48 citations in OpenAlex.

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  13. OncogenicMedComm · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Xiao XiongInstitute of Precision Cancer Medicine and Pathology, and Department of Pathology, School of Medicine, and Department of General Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, China.
Xiurong KeDepartment of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Lu WangInstitute of Precision Cancer Medicine and Pathology, and Department of Pathology, School of Medicine, and Department of General Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, China.
Yusheng LinInstitute of Precision Cancer Medicine and Pathology, and Department of Pathology, School of Medicine, and Department of General Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, China.
Shuhong WangInstitute of Precision Cancer Medicine and Pathology, and Department of Pathology, School of Medicine, and Department of General Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, China.
Zhimeng YaoInstitute of Precision Cancer Medicine and Pathology, and Department of Pathology, School of Medicine, and Department of General Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, China.
Kai LiInstitute of Precision Cancer Medicine and Pathology, and Department of Pathology, School of Medicine, and Department of General Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, China.
Yichen LuoInstitute of Precision Cancer Medicine and Pathology, and Department of Pathology, School of Medicine, and Department of General Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, China.
Fan LiuInstitute of Precision Cancer Medicine and Pathology, and Department of Pathology, School of Medicine, and Department of General Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, China.
Yunlong PanDepartment of General Surgery, The First Affiliated Hospital of Jinan University, and Institute of Precision Cancer Medicine and Pathology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
Sai-Ching J YeungDepartment of Emergency Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Wijnand HelfrichDepartment of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Hao ZhangDepartment of General Surgery, The First Affiliated Hospital of Jinan University, and Institute of Precision Cancer Medicine and Pathology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
First Affiliated Hospital of Jinan University · CNUniversity Medical Center Groningen · NLJinan University · CNShantou University Medical College · CNThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer vaccines critically rely on the availability of targetable immunogenic cancer-specific neoepitopes. However, mutation-based immunogenic neoantigens are rare or even non-existent in subgroups of cancer types. To address this issue, we exploited a cancer-specific aberrant transcription-induced chimeric RNA, designated A-P

Indexed as

Cancer VaccinesExtracellular VesiclesNeoplasmsAnimalsAntigens, NeoplasmDendritic CellsMiceRNAVaccinationAntigens, NeoplasmCancer VaccinesRNAEV-based cancer vaccinemutation-independent neoantigentranscription-induced chimeric RNA

Identifiers

PMID35927827
PMCPMC9451527
OpenAlexW4289890606

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.