Evidence map›Paper›PMID 35927727›Full record

Observational studyLipids in health and disease2022

Postprandial triglyceride levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants.

Karin G Stenkula, Lisa Esbjörnsson Klemendz, Claes Fryklund, Nils Wierup, Wathik Alsalim, Mona Landin-Olsson, Lena Trinh, Sven Månsson, Louise Bennet

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Lipids in health and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Karin G Stenkula *Department of Experimental Medical Sciences, Lund University, Lund, Sweden. karin.stenkula@med.lu.se.
Lisa Esbjörnsson Klemendz *Primary Health Care Region Skåne, Malmö, Sweden.
Claes FryklundDepartment of Experimental Medical Sciences, Lund University, Lund, Sweden.
Nils WierupLund University Diabetes Centre, Malmö, Sweden.
Wathik AlsalimLund University, Skåne University Hospital Lund, Lund, Sweden.
Mona Landin-OlssonLund University, Skåne University Hospital Lund, Lund, Sweden.
Lena TrinhMedical Radiation Physics, Department of Translational Medicine, Lund University, Malmö, Sweden.
Sven MånssonMedical Radiation Physics, Department of Translational Medicine, Lund University, Malmö, Sweden.
Louise BennetLund University, Skåne University Hospital Lund, Lund, Sweden.
Lund University · SESkåne University Hospital · SE

Funding

Skåne University funds against cancer N/ASwedish foundation for Strategic Research IRC15-0067Vetenskapsrådet 349-2006-237, 2009-1039, 2019-00978
6 · The paper itself

Abstract

purposePrevious studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities.

methodsThis observational study included 26 Iraqi and 16 Swedish-born men without T2D or clinical risk factors for CVD. An oral fat tolerance test (OFTT) was performed, where plasma triglycerides (p-TG) were measured for 6 h. mRNA expression and adipocyte size were measured in subcutaneous adipose tissue biopsies collected prior to OFTT, and magnetic resonance imaging was conducted to assess body fat distribution.

resultsThe median p-TG accumulation was higher and the clearance slower among Iraqis than Swedes. None of the groups reached their fasting p-TG (Iraqis 1.55 mmol/l; Swedes 0.95 mmol/l) after 6 h (Iraqis p-TG 3.10 mmol/l; Swedes p-TG 1.50 mmol/l). Adipocyte size, mRNA expression, and fat accumulation in the liver, muscle and abdomen were similar in both groups.

conclusionPostprandial p-TG levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants without CVD risk factors.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2Emigrants and ImmigrantsCD36 AntigensHumansIraqMalePostprandial PeriodRNA, MessengerSwedenTriglyceridesCD36 AntigensRNA, MessengerTriglyceridesAdipose tissueCardiovascular diseaseEthnicityFat distributionOral fat tolerance testPlasma triglyceridesType 2 diabetes

Identifiers

PMID35927727
PMCPMC9351238
OpenAlexW4289841306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.