Evidence map›Paper›PMID 35927622›Full record

Trial reportBMC neurology2022

Effect of an exercise intervention on global cognition after transient ischemic attack or minor stroke: the MoveIT randomized controlled trial.

Inger A Deijle, Roelofjan Hemmes, H Myrthe Boss, Edwin C de Melker, Bob T J van den Berg, Gert Kwakkel, Erwin van Wegen, Wendy M Bosboom, Henry C Weinstein, Sander M van Schaik and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 9 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 9 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Inger A DeijleDepartment of Neurology, OLVG, Amsterdam, The Netherlands.
Roelofjan HemmesDepartment of Neurology, OLVG, Amsterdam, The Netherlands.
H Myrthe BossDepartment of Neurology, Gelderse Vallei Hospital, Ede, The Netherlands.
Edwin C de MelkerDepartment of Cardiology, OLVG, Amsterdam, The Netherlands.
Bob T J van den BergDepartment of Respiratory Medicine, OLVG, Amsterdam, The Netherlands.
Gert KwakkelDepartment of Rehabilitation Medicine, Amsterdam UMC, location Vrije Universiteit Amsterdam, De Boelelaan 1118, Amsterdam, The Netherlands.
Erwin van WegenDepartment of Rehabilitation Medicine, Amsterdam UMC, location Vrije Universiteit Amsterdam, De Boelelaan 1118, Amsterdam, The Netherlands.
Wendy M BosboomBoard of directors, Rivierenland Hospital, Tiel, The Netherlands.
Henry C WeinsteinDepartment of Neurology, OLVG, Amsterdam, The Netherlands.
Sander M van SchaikDepartment of Neurology, OLVG, Amsterdam, The Netherlands.
Renske M Van den Berg-VosDepartment of Neurology, OLVG, Amsterdam, The Netherlands. R.vandenberg-vos@olvg.nl.
OLVG · NLAmsterdam Neuroscience · NLNorthwestern University · USZiekenhuis Gelderse Vallei · NLZiekenhuis Rivierenland · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with a transient ischemic attack (TIA) or ischemic stroke are at increased risk of developing cognitive impairment in the subacute phase. At present, the effects of exercise on cognitive functioning following a TIA or stroke are not fully known. The purpose of this trial was to investigate the effect of exercise on global cognition.

methodsThe MoveIT trial is a single-centre, observer-blinded, randomized controlled trial involving a 1-year exercise intervention consisting of a 12-week group exercise program, combined with three counselling visits to the physiotherapists over a 9-month period. The control group received standard care. The primary outcome was global cognitive functioning, assessed at one year, using the Montreal Cognitive Assessment (MoCA). Secondary outcomes included cardiorespiratory fitness, the cardiovascular profile, and attainment of secondary prevention targets, anxiety, depression and fatigue at one and two years.

resultsThe experimental group consisted of 60 patients, while the control group consisted of 59 patients. The mean age was 64.3 years and 41% were female. No between-group differences were found on global cognitive functioning (MD, 0.7 out of 30, 95% CI, - 0.2 to 1.6) or on secondary outcome measures at 12 months. The only significant between-group difference was found for fatigue, in favour of the experimental group at 12 months (MD, 0.6 out of 63, 95% CI, 0.1 to 1.1).

conclusionsNo benefit of this exercise intervention was found regarding global cognition. Future studies need to focus on optimizing rehabilitation strategies for this vulnerable group of patients.

trial registrationhttp://www.trialregister.nl . Unique identifier: NL3721 . Date first registration: 06-03-2013.

Indexed as

Ischemic Attack, TransientStrokeCognitionExercise TherapyFatigueFemaleHumansMaleMiddle AgedCognitionIschemic strokePhysical fitness trainingTransient ischemic attack

Identifiers

PMID35927622
PMCPMC9351151
OpenAlexW4289745174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.