Evidence map›Paper›PMID 35927578›Full record

ReviewNature reviews. Rheumatology2022

Sex- and gender-related differences in psoriatic arthritis.

Sanjana Tarannum, Ying-Ying Leung, Sindhu R Johnson, Jessica Widdifield, Vibeke Strand, Paula Rochon, Lihi Eder

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Review
  6. Article
  7. Review
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Global epidemiology of spondyloarthritis.Nature reviews. Rheumatology · 2025
    Review
  17. Article
  18. Article
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Sanjana TarannumWomen's College Research Institute and University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-0576-6278
Ying-Ying LeungSingapore General Hospital and Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0001-8492-6342
Sindhu R JohnsonToronto Western Hospital and University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-0591-2976
Jessica WiddifieldSunnybrook Research Institute and University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-7464-0460
Vibeke StrandDivision of Immunology/Rheumatology, Stanford University, Palo Alto, CA, USA.ORCID 0000-0003-4978-4072
Paula RochonWomen's College Research Institute and University of Toronto, Toronto, Ontario, Canada.
Lihi EderWomen's College Research Institute and University of Toronto, Toronto, Ontario, Canada. lihi.eder@wchospital.ca.ORCID 0000-0002-1473-1715
University of Toronto · CASingapore General Hospital · SGStanford University · USSunnybrook Health Science Centre · CA

Funding

CIHR
6 · The paper itself

Abstract

Psoriatic arthritis (PsA) is an inflammatory musculoskeletal disease with a chronic, progressive course. Various aspects of PsA, including its clinical features, disease course and response to treatment, are influenced by sociodemographic characteristics of the patient. This includes patient sex, the biological attributes associated with being male or female, and gender, a sociocultural construct that comprises attitudes, traits and behaviours associated with being a man or a woman. An understanding of sex- and gender-related differences in PsA, as well as their underlying mechanisms, is therefore important for individualized care. In this narrative review, the influence of sex and gender on PsA manifestation and course, patient function and quality of life, and their association with comorbidities are described. Sex- and gender-related disparities in response to advanced therapies and their potential underlying mechanisms are delineated. Differences in pathophysiological mechanisms between male and female patients including genetics, immune and hormonal mechanisms are discussed. Finally, fertility and pregnancy outcomes in PsA are outlined. By adopting sex and gender lenses, this review is aimed at highlighting key differences between male and female patients with PsA and uncovering mechanisms underlying these differences, ultimately promoting individualized care of men and women with PsA and informing future research in this area.

Indexed as

Arthritis, PsoriaticComorbidityFemaleHumansMaleQuality of LifeSex Factors

Identifiers

PMID35927578
OpenAlexW4289841180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.