Evidence map›Paper›PMID 35927505›Full record

Trial reportEuropean journal of clinical nutrition2022

A 12-month weight loss intervention in adults with obstructive sleep apnoea: is timing important? A step wedge randomised trial.

Helen Truby, Bradley A Edwards, Kaitlin Day, Denise M O'Driscoll, Alan Young, Ladan Ghazi, Claire Bristow, Kerryn Roem, Maxine P Bonham, Chiara Murgia and 2 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Maximizing outcomes by multimodal treatment in obstructive sleep apnea: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Helen TrubySchool of Human Movement and Nutrition Sciences, University of Queensland, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-1992-1649
Bradley A EdwardsDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
Kaitlin DaySchool of Clinical Sciences, Department of Nutrition, Dietetics and Food, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0003-3846-8568
Denise M O'DriscollEastern Health, Department of Respiratory and Sleep Medicine, Melbourne, VIC, Australia.
Alan YoungEastern Health, Department of Respiratory and Sleep Medicine, Melbourne, VIC, Australia.
Ladan GhaziSchool of Clinical Sciences, Department of Nutrition, Dietetics and Food, Monash University, Melbourne, VIC, Australia.
Claire BristowSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Kerryn RoemSchool of Clinical Sciences, Department of Nutrition, Dietetics and Food, Monash University, Melbourne, VIC, Australia.
Maxine P BonhamSchool of Clinical Sciences, Department of Nutrition, Dietetics and Food, Monash University, Melbourne, VIC, Australia.
Chiara MurgiaSchool of Agriculture and Food, Melbourne University, Melbourne, VIC, Australia.
Terry P HainesSchool of Primary and Allied Health Care, Monash University, Melbourne, VIC, Australia.
Garun S HamiltonSchool of Clinical Sciences, Monash University, Melbourne, VIC, Australia. garun.hamilton@monashhealth.org.ORCID http://orcid.org/0000-0002-1744-2839
Monash University · AUEastern Health · AUAustralian Regenerative Medicine Institute · AUMonash Health · AUThe University of Melbourne · AUThe University of Queensland · AU

Funding

Wellcome Trust 101167
6 · The paper itself

Abstract

BACKGROUND/

objectivesContinuous positive airway pressure (CPAP) concomitant with weight loss is a recommended treatment approach for adults with moderate-severe obstructive sleep apnoea (OSA) and obesity. This requires multiple synchronous behaviour changes. The aim of this study was to examine the effectiveness of a 6-month lifestyle intervention and to determine whether the timing of starting a weight loss attempt affects weight change and trajectory after 12 months in adults newly diagnosed with moderate-severe OSA and treated at home with overnight CPAP.

methodsUsing a stepped-wedge design, participants were randomised to commence a six-month lifestyle intervention between one and six-months post-enrolment, with a 12-month overall follow-up. Adults (n = 60, 75% males, mean age 49.4 SD 10.74 years) newly diagnosed with moderate-severe OSA and above a healthy weight (mean BMI 34.1 SD 4.8) were recruited.

resultsAfter 12 months, exposure to the intervention (CPAP and lifestyle) resulted in a 3.7 (95% CI: 2.6 to 4.8, p < 0.001) kg loss of weight compared to the control condition (CPAP alone). Timing of the weight loss attempt made no difference to outcomes at 12 months. When exposed to CPAP only (control period) there was no change in body weight (Coef, [95% CI] 0.03, [-0.3 to 0.36], p = 0.86).

conclusionsThe lifestyle intervention resulted in a modest reduction in body weight, while timing of commencement did not impact the degree of weight loss at 12 months. These findings support the recommendation of adjunctive weight-loss interventions within six-months of starting CPAP.

Indexed as

Sleep Apnea, ObstructiveAdultContinuous Positive Airway PressureFemaleHumansLife StyleMaleMiddle AgedObesityWeight Loss

Identifiers

PMID35927505
PMCPMC9708544
OpenAlexW4289780765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.