ArticleScientific reports2022
Left sided breast cancer is associated with aggressive biology and worse outcomes than right sided breast cancer.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Does Laterality in Breast Cancer still have the Importance to be Studied? A Meta-analysis of Patients with Breast Cancer.Current medicinal chemistry · 2024Pooled it
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- Predictors of severe immune-related adverse events during first-line immune checkpoint inhibitor therapy for advanced non-small cell lung cancer.Scientific reports · 2026Article
- Comparison of Survival Outcomes Among Women With Breast Cancer Across Different Health Systems in Veracruz, Mexico.Cureus · 2026Article
- High-Throughput In Vivo Subcellular Analysis of Gold Nanoparticles for Tumor Mitochondrial Targeting.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Postmastectomy radiotherapy in pN1 breast cancer: Survival outcomes and prognostic factors from a single-institution cohort.PloS one · 2026Article
- Characteristics of Breast Cancer Patients in Northeastern Iran: A Retrospective Cohort Study.Breast cancer : basic and clinical research · 2026Article
- Article
- Tumor location, genomic alterations, and radiomic features as predictors of survival in glioblastoma: a Multi-Modal analysis.Neuroradiology · 2025Article
- Relationship of diabetes mellitus with prognostic factors in breast cancer.World journal of experimental medicine · 2025Article
- Risk factors of breast cancer patients developing multiple primary cancers: a retrospective study and establishing/testing of machine learning models.BMC medical informatics and decision making · 2025Article
- Prevalence and clinicopathological features of human epidermal growth factor receptor-2-low breast cancers: A single-center experience.The Journal of international medical research · 2025Observational
- The association between mammography reports and women's age using retrospective data form a medical system.Frontiers in global women's health · 2025Article
- Breast cancer - Clinicopathological profile at a Tertiary Cancer Center in India.Archives of Razi Institute · 2024Article
- Survival analysis for patients with metachronous contralateral breast cancer: Insights from a retrospective study.Oncology letters · 2024Article
- Article
- Association of metastatic pattern in breast cancer with tumor and patient-specific factors: a nationwide autopsy study using artificial intelligence.Breast cancer (Tokyo, Japan) · 2024Article
- Asymmetries of Left and Right Adrenal Glands in Neural Innervation and Glucocorticoids Production.International journal of molecular sciences · 2023Article
- The tendency of segmental distribution of hepatic metastasis according to couinaud classification: a comparison of portal versus systemic route of metastatis due to primary colorectal and breast tumors.Annals of medicine and surgery (2012) · 2023Article
- The Yin and Yang of Breast Cancer: Ion Channels as Determinants of Left-Right Functional Differences.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Breast cancer is more common on the left side than the right side. We aim to evaluate differences in clinicopathological and genomic characteristics based on laterality. We analyzed survival outcomes and clinical characteristics of 881,320 patients recorded by the Surveillance, Epidemiology, and End Results (SEER) program. The Cancer Genome Atlas (TCGA) was used to explore genomic and clinical features from 1,062 patients. Gene expression data was used to quantitate cytolytic activity and hallmark gene-sets were used for gene set enrichment analysis. An institutional retrospective review was conducted on 155 patients treated with neoadjuvant chemotherapy (NACT). Patient characteristics were summarized by pathological complete response (pCR). Left sided tumors were found to be more prevalent than right sided tumors. No major clinicopathological differences were noted by laterality. Left sided breast cancer demonstrated poorer outcomes versus right sided tumors (HR 1.05, 95% CI 1.01-1.08; p = 0.011). Cell proliferation gene sets, including E2F Targets, G2M Checkpoint, Mitotic spindle, and MYC Targets, were enriched on the left side compared to the right. Left sided tumors had lower pCR rates versus right sided tumors (15.4% versus 29.9%, p = 0.036). Our findings suggest that left sided breast cancer is associated with aggressive biology and worse outcomes compared to right sided breast cancer.
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