Evidence map›Paper›PMID 35927368›Full record

ArticleHepatology international2022

Diversity of the nucleic acid forms of circulating HBV in chronically infected patients and its impact on viral cycle.

Jules Sotty, Pierre Bablon, Bouchra Lekbaby, Jérémy Augustin, Morgane Girier-Dufournier, Lucas Langlois, Céline Dorival, Fabrice Carrat, Stanislas Pol, Hélène Fontaine and 6 more

Registry-linked trialOpen access · greenAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Hepatology international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01953458 (Therapeutic Option for Hepatitis B and C), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01953458 unknown statusnot on this map

Therapeutic Option for Hepatitis B and C: a French Cohort

TypeobservationalSponsorANRS, Emerging Infectious DiseasesRan2012 to 2024Enrolled20,902ConditionsViral Hepatitis B, Viral Hepatitis C
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Jules SottySorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche de Saint Antoine (CRSA), Paris, France.
Pierre BablonSorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche de Saint Antoine (CRSA), Paris, France.
Bouchra LekbabySorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche de Saint Antoine (CRSA), Paris, France.
Jérémy AugustinSorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche de Saint Antoine (CRSA), Paris, France.
Morgane Girier-DufournierSorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche de Saint Antoine (CRSA), Paris, France.
Lucas LangloisSorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche de Saint Antoine (CRSA), Paris, France.
Céline DorivalSorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Département de santé publique, Hôpital Saint-Antoine, AP-HP, Paris, France.
Fabrice CarratSorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Département de santé publique, Hôpital Saint-Antoine, AP-HP, Paris, France.
Stanislas PolUniversité de Paris, AP-HP, Département d'hépatologie, Hôpital Cochin, Paris, France.
Hélène FontaineUniversité de Paris, AP-HP, Département d'hépatologie, Hôpital Cochin, Paris, France.
Nazim SaricaInstitut de Génétique Humaine, Université de Montpellier, Laboratoire de Virologie Moléculaire CNRS-UMR9002, Montpellier, France.
Christine NeuveutInstitut de Génétique Humaine, Université de Montpellier, Laboratoire de Virologie Moléculaire CNRS-UMR9002, Montpellier, France.
Chantal HoussetSorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche de Saint Antoine (CRSA), Paris, France.
Dina KremdsorfSorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche de Saint Antoine (CRSA), Paris, France.
Aurélie Schnuriger *Sorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche de Saint Antoine (CRSA), Paris, France.
Patrick Soussan *Sorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche de Saint Antoine (CRSA), Paris, France. patrick.soussan@inserm.fr.ORCID http://orcid.org/0000-0003-2706-7371
Inserm · FRCentre National de la Recherche Scientifique · FRHôpital Cochin · FR

Funding

Agence Nationale de Recherches sur le Sida et les Hépatites Virales ECTZ 103985Agence Nationale de Recherches sur le Sida et les Hépatites Virales ECTZ 163186FRM EQU202003010517
6 · The paper itself

Abstract

backgroundBesides the prototypical hepatitis B virus (HBV) infectious particle, which contains a full-length double-stranded DNA (flDNA), additional circulating virus-like particles, which carry pregenomic RNA (pgRNA), spliced1RNA (sp1RNA) or spliced-derived DNA (defDNA) forms have been described. We aimed to determine the level of these four circulating forms in patients and to evaluate their impact on viral lifecycle.

methodsChronic HBV untreated patients (n = 162), included in the HEPATHER cohort, were investigated. Pangenomic qPCRs were set up to quantify the four circulating forms of HBV nucleic acids (HBV

resultsHierarchical clustering individualized two clusters of HBV

conclusionBesides the critical role of HBV replication in circulating HBV CLINICAL

trial registrationPatients were included from a prospective multicenter French national cohort (ANRS CO22 HEPATHER, NCT01953458).

Indexed as

Hepatitis BHepatitis B, ChronicNucleic AcidsDNA, ViralHepatitis B virusHumansProspective StudiesRNARNA, ViralVirus ReplicationDNA, ViralNucleic AcidsRNARNA, ViralAlternative splicingChronic hepatitisChronic infectionHBVHBV pregenomic RNALiver diseaseViral circulating formsViral cycleViral genome diversityViral hepatitis

Identifiers

PMID35927368
OpenAlexW4289782464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.