ArticleSurgical case reports2022
Signet-ring cell carcinoma of the appendix with ganglioneuromatosis: a case report.
Article in Surgical case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Primary Signet Ring Cell Adenocarcinoma of the Appendix Masquerading as Acute Appendicitis: A Diagnostic Pitfall.Iranian journal of pathology · 2026Article
- Primary signet ring cell carcinoma of the appendix presenting as gangrenous appendicitis with peritonitis: a case report.Annals of medicine and surgery (2012) · 2025Article
- Signet ring cell carcinoma of the appendix and terminal ileum: A case report.World journal of gastrointestinal oncology · 2025Article
- Appendiceal Signet Ring Cell Carcinoma: An Atypical Cause of Acute Appendicitis-A Case Study and Review of Current Knowledge.Diagnostics (Basel, Switzerland) · 2023Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary cancer of the appendix, especially signet-ring cell carcinoma, is an uncommon disease, and it is rarely suspected before surgery. Diffuse intestinal ganglioneuromatosis that is not associated with neurofibromatosis-1 or multiple endocrine neoplasia 2b is also rare. The most frequent symptoms caused by it are changes in bowel habits, abdominal pain, and occlusive episodes. CASE PRESENTATION: The patient was a 48-year-old woman who had a month-long history of chronic abdominal pain, fullness, constipation, and diarrhoea. Enhanced computed tomography showed a 100-mm irregular swelling in the appendix and thickening of the appendiceal wall with cystic dilatation. Based on a preoperative diagnosis of appendiceal cancer, the patient underwent laparoscopic ileocecal resection with D3 lymph node dissection. Pathological diagnosis revealed a signet-ring cell carcinoma of the appendix with ganglioneuromatosis. The patient completed four courses of capecitabine plus oxaliplatin (CAPEOX) as postoperative adjuvant chemotherapy, and 23-month postoperative outcome was noneventful without recurrence.
conclusionWe report a signet-ring cell carcinoma of the appendix that was detected early because of its presence with ganglioneuromatosis.
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