Evidence map›Paper›PMID 35927308›Full record

ArticleScientific reports2022

Game-theoretic link relevance indexing on genome-wide expression dataset identifies putative salient genes with potential etiological and diapeutics role in colorectal cancer.

Vishwa Jyoti Baruah, Papori Neog Bora, Bhaswati Sarmah, Priyakshi Mahanta, Ankumon Sarmah, Stefano Moretti, Rajnish Kumar, Surajit Borkotokey

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Vishwa Jyoti BaruahCentre for Biotechnology and Bioinformatics, Dibrugarh University, Dibrugarh, 786004, Assam, India. vishwabaruah@gmail.com.
Papori Neog BoraDepartment of Mathematics, Dibrugarh University, Dibrugarh, 786004, Assam, India.
Bhaswati SarmahDepartment of Plant Breeding and Genetics, Assam Agricultural University, Jorhat, 785013, Assam, India.
Priyakshi MahantaCentre for Computer Science and Applications, Dibrugarh University, Dibrugarh, 786004, Assam, India.
Ankumon SarmahCentre for Computer Science and Applications, Dibrugarh University, Dibrugarh, 786004, Assam, India.
Stefano MorettiCNRS, LAMSADE, Université Paris-Dauphine, PSL Research University, Paris, France.
Rajnish KumarEconomics Group, Queen's Management School, Queen's University Belfast, Belfast, BT9 5EE, UK.
Surajit BorkotokeyDepartment of Mathematics, Dibrugarh University, Dibrugarh, 786004, Assam, India. sborkotokey@dibru.ac.in.
Dibrugarh University · INAssam Agricultural University · INQueen's University Belfast · GBUniversité Paris Sciences et Lettres · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diapeutics gene markers in colorectal cancer (CRC) can help manage mortality caused by the disease. We applied a game-theoretic link relevance Index (LRI) scoring on the high-throughput whole-genome transcriptome dataset to identify salient genes in CRC and obtained 126 salient genes with LRI score greater than zero. The biomarkers database lacks preliminary information on the salient genes as biomarkers for all the available cancer cell types. The salient genes revealed eleven, one and six overrepresentations for major Biological Processes, Molecular Function, and Cellular components. However, no enrichment with respect to chromosome location was found for the salient genes. Significantly high enrichments were observed for several KEGG, Reactome and PPI terms. The survival analysis of top protein-coding salient genes exhibited superior prognostic characteristics for CRC. MIR143HG, AMOTL1, ACTG2 and other salient genes lack sufficient information regarding their etiological role in CRC. Further investigation in LRI methodology and salient genes to augment the existing knowledge base may create new milestones in CRC diapeutics.

Indexed as

Colorectal NeoplasmsGene Expression Regulation, NeoplasticAngiomotinsBiomarkers, TumorGene Expression ProfilingHumansMembrane ProteinsPrognosisSurvival AnalysisTranscriptomeAMOTL1 protein, humanAngiomotinsBiomarkers, TumorMembrane Proteins

Identifiers

PMID35927308
PMCPMC9352798
OpenAlexW4289774551

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.