Evidence map›Paper›PMID 35927285›Full record

ArticleScientific reports2022

Predicting real world spatial disorientation in Alzheimer's disease patients using virtual reality navigation tests.

Vaisakh Puthusseryppady, Sol Morrissey, Hugo Spiers, Martyn Patel, Michael Hornberger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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  14. A cognitive-motor framework for spatial navigation in aging and early-stage Alzheimer's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Vaisakh PuthusseryppadyNorwich Medical School, 2.04 Bob Champion Research and Education Building, University of East Anglia, Norwich, NR4 7TJ, UK.
Sol MorrisseyNorwich Medical School, 2.04 Bob Champion Research and Education Building, University of East Anglia, Norwich, NR4 7TJ, UK.
Hugo SpiersDivision of Psychology and Language Sciences, Department of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, WC1H 0AP, UK.
Martyn PatelNorwich Medical School, 2.04 Bob Champion Research and Education Building, University of East Anglia, Norwich, NR4 7TJ, UK.
Michael HornbergerNorwich Medical School, 2.04 Bob Champion Research and Education Building, University of East Anglia, Norwich, NR4 7TJ, UK. m.hornberger@uea.ac.uk.
University of East Anglia · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spatial navigation impairments in Alzheimer's disease (AD) have been suggested to underlie patients experiencing spatial disorientation. Though many studies have highlighted navigation impairments for AD patients in virtual reality (VR) environments, the extent to which these impairments predict a patient's risk for spatial disorientation in the real world is still poorly understood. The aims of this study were to (a) investigate the spatial navigation abilities of AD patients in VR environments as well as in a real world community setting and (b) explore whether we could predict patients at a high risk for spatial disorientation in the community based on their VR navigation. Sixteen community-dwelling AD patients and 21 age/gender matched controls were assessed on their egocentric and allocentric navigation abilities in VR environments using the Virtual Supermarket Test (VST) and Sea Hero Quest (SHQ) as well as in the community using the Detour Navigation Test (DNT). When compared to controls, AD patients exhibited impairments on the VST, SHQ, and DNT. For patients, only SHQ wayfinding distance and wayfinding duration significantly predicted composite disorientation score on the DNT (β = 0.422, p = 0.034, R

Indexed as

Alzheimer DiseaseSpatial NavigationVirtual RealityConfusionHumansNeuropsychological Tests

Identifiers

PMID35927285
PMCPMC9352716
OpenAlexW4289766546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.