Evidence map›Paper›PMID 35927272›Full record

Articlenpj aging2022

Genetic associations with healthy ageing among Chinese adults.

Xuling Chang, Yan-Feng Zhou, Ling Wang, Jianjun Liu, Jian-Min Yuan, Chiea-Chuen Khor, Chew-Kiat Heng, An Pan, Woon-Puay Koh, Rajkumar Dorajoo

Open access · hybridAbstract read
In one paragraph

Article in npj aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Xuling ChangDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
Yan-Feng ZhouDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.ORCID http://orcid.org/0000-0003-1967-1229
Ling WangGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.
Jianjun LiuGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.
Jian-Min YuanDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15232, USA.
Chiea-Chuen KhorGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.ORCID http://orcid.org/0000-0002-1128-4729
Chew-Kiat HengDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
An PanDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Woon-Puay KohHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore. kohwp@nus.edu.sg.ORCID http://orcid.org/0000-0002-5674-6341
Rajkumar DorajooGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore. dorajoor@gis.a-star.edu.sg.ORCID http://orcid.org/0000-0001-6608-2051
Agency for Science, Technology and Research · SGNational University of Singapore · SGHuazhong University of Science and Technology · CNUniversity of Pittsburgh · US

Funding

Prospective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0M
Cancer epidemiology cohorts in Shanghai and Singapore UM1CA182876 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2014 to 2018
$4.3M
The Singapore Chinese Health StudyU01CA182876 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2019 to 2019
$150k
NCI NIH HHS R01 CA144034NCI NIH HHS U01 CA182876NCI NIH HHS UM1 CA182876
6 · The paper itself

Abstract

The genetic basis of overall healthy ageing, especially among the East-Asian population is understudied. We conducted a genome-wide association study among 1618 Singapore Chinese elderly participants (65 years or older) ascertained to have aged healthily and compared their genome-wide genotypes to 6221 participants who did not age healthily, after a 20-year follow-up. Two genetic variants were identified (P

Identifiers

PMID35927272
PMCPMC9158790
OpenAlexW4225272096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.