Articlenpj aging2022
The deleterious effects of old social partners on Drosophila lifespan and stress resistance.
Article in npj aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ageing effects of social environments in 'non-social' insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Pooled it
- Distribution Analysis of the Lifespan Trait in Drosophila.International journal of molecular sciences · 2025Article
- Perception and Longevity Control in Invertebrate Model Organisms-A Mini-Review of Recent Advances.Biomolecules · 2025Review
- Review
- Sociosexual Exposure Has Opposing Effects on Male and Female Actuarial Senescence in the Fruit Fly Drosophila melanogaster.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Social interactions play important roles in the modulation of behavior, physiology, and, potentially, lifespan. Although longevity has been studied extensively in different model organisms, due to the complexity of social environments, the social modulation of aging remains poorly investigated. The present study used the fruit fly, Drosophila melanogaster, as a model to study lifespan and stress resistance under different social conditions. Our experiments first showed that social isolation increased fly lifespan, suggesting a potential deleterious effect of social companions. Furthermore, we exposed flies to different aged social partners and found that living with old animals significantly reduced lifespan and stress resistance in young animals. In contrast, living with young animals increased old animal lifespan, although the effects were less robust. Overall, our results suggest that while social interaction can influence fly health, specific social partners may have more pronounced effects than others. This study provides new evidence that different social environments have significant impacts on animal physiology and longevity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.